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    CG11249 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40409, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG11249provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0037115
    Locus tag
    Dmel_CG11249
    See related
    AllianceGenome:FB:FBgn0037115
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG11249
    Summary
    Predicted to enable pyruvate kinase activity. Predicted to be involved in canonical glycolysis and pyruvate biosynthetic process. Predicted to be located in cytosol. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG11249 in Genome Data Viewer
    Location:
    78E3-78E3; 3-47 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (21672139..21674518)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (21665239..21667618)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR43977 Neighboring gene long non-coding RNA:CR45920 Neighboring gene mir-316 stem loop Neighboring gene Amyotrophic lateral sclerosis 2 Neighboring gene antisense RNA:CR43979 Neighboring gene uncharacterized protein Neighboring gene Seminal fluid protein 78E

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Metabolomic analysis of Drosophila melanogaster larvae lacking pyruvate kinase. Heidarian Y, et al. G3 (Bethesda), 2023 Dec 29. PMID 37792629, Free PMC Article
    2. The RNA export factor, Nxt1, is required for tissue specific transcriptional regulation. Caporilli S, et al. PLoS Genet, 2013 Jun. PMID 23754955, Free PMC Article
    3. Translational profiling of clock cells reveals circadianly synchronized protein synthesis. Huang Y, et al. PLoS Biol, 2013 Nov. PMID 24348200, Free PMC Article
    4. Wake-up-call, a lin-52 paralogue, and Always early, a lin-9 homologue physically interact, but have opposing functions in regulating testis-specific gene expression. Doggett K, et al. Dev Biol, 2011 Jul 15. PMID 21570388, Free PMC Article
    5. CRISPR/Cas9 mediated genetic resource for unknown kinase and phosphatase genes in Drosophila. Wu M, et al. Sci Rep, 2020 Apr 30. PMID 32355295, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables potassium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pyruvate kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables pyruvate kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in canonical glycolysis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in glycolytic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glycolytic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in pyruvate biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG11249-PA
    NP_649346.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      21672139..21674518
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_141089.1 → NP_649346.1  uncharacterized protein Dmel_CG11249 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649346.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MR79, Q9VNZ9
      Related
      FBpp0078083, FBtr0078429
      Conserved Domains (2) summary
      pfam02887
      Location:492 → 594
      PK_C; Pyruvate kinase, alpha/beta domain
      cl23794
      Location:158 → 332
      Pyruvate_Kinase; Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8MR79 Q8MR79
    Q9VNZ9 Q9VNZ9

    Gene LinkOut

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