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    Sfxn2 Sideroflexin 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40080, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Sfxn2provided by FlyBase
    Official Full Name
    Sideroflexin 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0036843
    Locus tag
    Dmel_CG6812
    See related
    AllianceGenome:FB:FBgn0036843
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG6812; Dmel\CG6812; SFXN3
    Summary
    Enables L-serine transmembrane transporter activity. Involved in serine import into mitochondrion. Located in mitochondrion. Is expressed in adult head; adult heart; and organism. Orthologous to human SFXN2 (sideroflexin 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Sfxn2 in Genome Data Viewer
    Location:
    75F6-75F6; 3-45 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (19063165..19066151)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (19056265..19059251)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene UDP-glycosyltransferase family 316 member A1 Neighboring gene Mitogen-activated protein kinase phosphatase 3 Neighboring gene long non-coding RNA:CR45386

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Sideroflexin 3 is an α-synuclein-dependent mitochondrial protein that regulates synaptic morphology. Amorim IS, et al. J Cell Sci, 2017 Jan 15. PMID 28049716, Free PMC Article
    2. SFXN1 is a mitochondrial serine transporter required for one-carbon metabolism. Kory N, et al. Science, 2018 Nov 16. PMID 30442778, Free PMC Article
    3. The Adaptive Significance of Natural Genetic Variation in the DNA Damage Response of Drosophila melanogaster. Svetec N, et al. PLoS Genet, 2016 Mar. PMID 26950216, Free PMC Article
    4. A genetic screen and transcript profiling reveal a shared regulatory program for Drosophila linker histone H1 and chromatin remodeler CHD1. Kavi H, et al. G3 (Bethesda), 2015 Jan 27. PMID 25628309, Free PMC Article
    5. Transient junction anisotropies orient annular cell polarization in the Drosophila airway tubes. Hosono C, et al. Nat Cell Biol, 2015 Dec. PMID 26551273

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables L-serine transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables monoatomic ion transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitochondrial transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of one-carbon metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in serine import into mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in serine import into mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrial inner membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    sideroflexin 2
    Names
    CG6812-PA
    Sfxn2-PA
    sideroflexin

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      19063165..19066151
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_140829.3 → NP_649086.2  sideroflexin 2 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649086.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8SZ96, Q9VVW3
      Related
      FBpp0074792
      Conserved Domains (1) summary
      pfam03820
      Location:15 → 327
      Mtc; Tricarboxylate carrier
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VVW3.2 Q9VVW3

    Gene LinkOut

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