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    Cyp312a1 Cytochrome P450 312a1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40005, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cyp312a1provided by FlyBase
    Official Full Name
    Cytochrome P450 312a1provided by FlyBase
    Primary source
    FLYBASE:FBgn0036778
    Locus tag
    Dmel_CG5137
    See related
    AllianceGenome:FB:FBgn0036778
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    312a1; CG5137; Dmel\CG5137; P450 IV
    Summary
    Predicted to enable several functions, including heme binding activity; iron ion binding activity; and monooxygenase activity. Is expressed in adult head; gonad; and organism. Human ortholog(s) of this gene implicated in several diseases, including aromatase excess syndrome; bladder neck obstruction; endometriosis (multiple); ovarian disease (multiple); and prostate disease (multiple). Orthologous to human CYP19A1 (cytochrome P450 family 19 subfamily A member 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Cyp312a1 in Genome Data Viewer
    Location:
    75B11-75B11; 3-45 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (18128940..18132689, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (18122040..18125789, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44669 Neighboring gene geko

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Geko, a novel gene involved in olfaction in Drosophila melanogaster. Shiraiwa T, et al. J Neurogenet, 2000 Sep. PMID 10992166
    2. Male specific expression of a cytochrome P450 (Cyp312a1) in Drosophila melanogaster. Kasai S, et al. Biochem Biophys Res Commun, 2003 Jan 24. PMID 12559957
    3. Metabolic activation and toxicological evaluation of polychlorinated biphenyls in Drosophila melanogaster. Idda T, et al. Sci Rep, 2020 Dec 9. PMID 33299007, Free PMC Article
    4. The Drosophila Post-mating Response: Gene Expression and Behavioral Changes Reveal Perdurance and Variation in Cross-Tissue Interactions. Newell NR, et al. G3 (Bethesda), 2020 Mar 5. PMID 31907222, Free PMC Article
    5. The Sf1-related nuclear hormone receptor Hr39 regulates Drosophila female reproductive tract development and function. Allen AK, et al. Development, 2008 Jan. PMID 18077584

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    cytochrome P450 312a1
    Names
    CG5137-PA
    CG5137-PB
    Cyp312a1-PA
    Cyp312a1-PB
    cytochrome P450
    NP_001262008.1
    NP_649030.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      18128940..18132689 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001275079.1 → NP_001262008.1  cytochrome P450 312a1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262008.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q1ECB7, Q9VVN6
      UniProtKB/TrEMBL
      M9PI92
      Conserved Domains (1) summary
      pfam00067
      Location:35 → 505
      p450; Cytochrome P450

    2. NM_140773.3 → NP_649030.1  cytochrome P450 312a1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649030.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q1ECB7, Q9VVN6
      UniProtKB/TrEMBL
      M9PI92
      Related
      FBpp0074901
      Conserved Domains (1) summary
      pfam00067
      Location:35 → 505
      p450; Cytochrome P450
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PI92 M9PI92
    Q9VVN6.1 Q9VVN6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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