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    Tsen54 tRNA splicing endonuclease subunit 54 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39397, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tsen54provided by FlyBase
    Official Full Name
    tRNA splicing endonuclease subunit 54provided by FlyBase
    Primary source
    FLYBASE:FBgn0036266
    Locus tag
    Dmel_CG5626
    See related
    AllianceGenome:FB:FBgn0036266
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG5626; Dmel\CG5626; TSEN54
    Summary
    Involved in tRNA processing. Predicted to be part of tRNA-intron endonuclease complex. Used to study pontocerebellar hypoplasia type 4. Human ortholog(s) of this gene implicated in pontocerebellar hypoplasia type 2A; pontocerebellar hypoplasia type 4; and pontocerebellar hypoplasia type 5. Orthologous to human TSEN54 (tRNA splicing endonuclease subunit 54). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Tsen54 in Genome Data Viewer
    Location:
    69A2-69A2; 3-38 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (12204123..12206022, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (12197223..12199122, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Adenylate kinase 1 Neighboring gene approximated Neighboring gene long non-coding RNA:CR43991 Neighboring gene uncharacterized protein Neighboring gene Porphobilinogen synthase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A conserved motif controls nuclear localization of Drosophila Muscleblind. Fernandez-Costa JM, et al. Mol Cells, 2010 Jul. PMID 20652497
    2. Mutations in Drosophila tRNA processing factors cause phenotypes similar to Pontocerebellar Hypoplasia. Schmidt CA, et al. Biol Open, 2022 Mar 15. PMID 35132432, Free PMC Article
    3. RNA kinase CLP1/Cbc regulates meiosis initiation in spermatogenesis. Wu J, et al. Hum Mol Genet, 2021 Aug 12. PMID 33864361, Free PMC Article
    4. Molecular determinants of metazoan tricRNA biogenesis. Schmidt CA, et al. Nucleic Acids Res, 2019 Jul 9. PMID 31032518, Free PMC Article
    5. Deficiency of ValRS-m Causes Male Infertility in Drosophila melanogaster. Duan X, et al. Int J Mol Sci, 2024 Jul 8. PMID 39000597, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in tRNA processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in tRNA-type intron splice site recognition and cleavage IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of tRNA-intron endonuclease complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    tRNA splicing endonuclease subunit 54
    Names
    CG5626-PA
    Tsen54-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      12204123..12206022 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_140302.2 → NP_648559.1  tRNA splicing endonuclease subunit 54 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648559.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      I1WYI0, Q9VTV4
      Related
      FBpp0075748
      Conserved Domains (1) summary
      pfam12928
      Location:66 → 129
      tRNA_int_end_N2; tRNA-splicing endonuclease subunit sen54 N-term
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VTV4 Q9VTV4

    Gene LinkOut

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