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    Prdm13 PR/SET domain 13 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38713, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Prdm13provided by FlyBase
    Official Full Name
    PR/SET domain 13provided by FlyBase
    Primary source
    FLYBASE:FBgn0035687
    Locus tag
    Dmel_CG13296
    See related
    AllianceGenome:FB:FBgn0035687
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG13296; Dmel\CG13296; PRDM13
    Summary
    Predicted to enable chromatin binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in several structures, including central brain primordium; embryonic stomatogastric nervous system; ganglia; stomatogastric nervous system primordium; and ventral nerve cord primordium. Used to study North Carolina macular dystrophy. Human ortholog(s) of this gene implicated in pontocerebellar hypoplasia. Orthologous to human PRDM13 (PR/SET domain 13). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Prdm13 in Genome Data Viewer
    Location:
    65A7-65A7; 3-16 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (6163127..6164682)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (6156227..6157782)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45744 Neighboring gene Cuticular protein 65Az Neighboring gene fiery mountain Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A novel duplication of PRMD13 causes North Carolina macular dystrophy: overexpression of PRDM13 orthologue in drosophila eye reproduces the human phenotype. Manes G, et al. Hum Mol Genet, 2017 Nov 15. PMID 28973654
    2. Rapid and efficient cDNA library screening by self-ligation of inverse PCR products (SLIP). Hoskins RA, et al. Nucleic Acids Res, 2005 Dec 2. PMID 16326860, Free PMC Article
    3. The genetic architecture of odor-guided behavior in Drosophila melanogaster. Anholt RR, et al. Behav Genet, 2001 Jan. PMID 11529271
    4. Generation of a versatile BiFC ORFeome library for analyzing protein-protein interactions in live Drosophila. Bischof J, et al. Elife, 2018 Sep 24. PMID 30247122, Free PMC Article
    5. Transcriptional regulators form diverse groups with context-dependent regulatory functions. Stampfel G, et al. Nature, 2015 Dec 3. PMID 26550828

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables chromatin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    PR/SET domain 13
    Names
    CG13296-PA
    Prdm13-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      6163127..6164682
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_139775.2 → NP_648032.1  PR/SET domain 13 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648032.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VRV0
      Related
      FBpp0076705
      Conserved Domains (4) summary
      COG5048
      Location:280 → 380
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:323 → 343
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:406 → 427
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:336 → 358
      zf-H2C2_2; Zinc-finger double domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VRV0 Q9VRV0

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