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    Jon65Aii Jonah 65Aii [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38684, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Jon65Aiiprovided by FlyBase
    Official Full Name
    Jonah 65Aiiprovided by FlyBase
    Primary source
    FLYBASE:FBgn0035666
    Locus tag
    Dmel_CG6580
    See related
    AllianceGenome:FB:FBgn0035666
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG6580; Dmel\CG6580; Jon65A; SP153
    Summary
    Predicted to enable serine-type endopeptidase activity. Predicted to be involved in innate immune response and proteolysis. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Jon65Aii in Genome Data Viewer
    Location:
    65A3-65A4; 3-16 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (6052321..6053215)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (6045421..6046315)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Jonah 65Aiv Neighboring gene Jonah 65Aiii Neighboring gene Jonah 65Ai Neighboring gene tantalus

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Nonlinear expression patterns and multiple shifts in gene network interactions underlie robust phenotypic change in Drosophila melanogaster selected for night sleep duration. Souto-Maior C, et al. PLoS Comput Biol, 2023 Aug. PMID 37561813, Free PMC Article
    2. Developmental and functional analysis of Jonah gene expression. Carlson JR, et al. Dev Biol, 1985 Apr. PMID 2416611
    3. Spaceflight and simulated microgravity conditions increase virulence of Serratia marcescens in the Drosophila melanogaster infection model. Gilbert R, et al. NPJ Microgravity, 2020. PMID 32047838, Free PMC Article
    4. The Jonah genes: a new multigene family in Drosophila melanogaster. Carlson JR, et al. Dev Biol, 1985 Apr. PMID 2416610
    5. Gp93, the Drosophila GRP94 ortholog, is required for gut epithelial homeostasis and nutrient assimilation-coupled growth control. Maynard JC, et al. Dev Biol, 2010 Mar 15. PMID 20044986, Free PMC Article

    See all (48) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type endopeptidase activity ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    jonah 65Aii
    Names
    CG6580-PA
    Jon65Aii-PA
    jonah 65A
    NP_648014.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      6052321..6053215
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_139757.2 → NP_648014.1  jonah 65Aii [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648014.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      F2FBC1, Q9VRS8
      Related
      FBpp0076750
      Conserved Domains (2) summary
      smart00020
      Location:36 → 251
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:37 → 254
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VRS8 Q9VRS8

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