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    Roc1b Regulator of cullins 1b [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 53445, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Roc1bprovided by FlyBase
    Official Full Name
    Regulator of cullins 1bprovided by FlyBase
    Primary source
    FLYBASE:FBgn0040291
    Locus tag
    Dmel_CG16988
    See related
    AllianceGenome:FB:FBgn0040291
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:AT21612; CG16988; Dmel\CG16988; dRoc1b; Roc; roc1b; ROC1b; ROC1B; Roc2; ROC2
    Summary
    Enables cullin family protein binding activity and ubiquitin protein ligase activity. Involved in lipid storage and protein ubiquitination. Part of Cul3-RING ubiquitin ligase complex. Is expressed in organism and wing disc. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Roc1b in Genome Data Viewer
    Location:
    61C1-61C1; 3-0.5 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (357981..358486)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (357981..358486)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Protein tyrosine phosphatase Meg Neighboring gene methuselah Neighboring gene uncharacterized protein Neighboring gene Cell division cycle 5 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene trachealess Neighboring gene long non-coding RNA:CR45378

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila Roc1a encodes a RING-H2 protein with a unique function in processing the Hh signal transducer Ci by the SCF E3 ubiquitin ligase. Noureddine MA, et al. Dev Cell, 2002 Jun. PMID 12062088
    2. RING finger specificity in SCF-driven protein destruction. Jin J, et al. Dev Cell, 2002 Jun. PMID 12062077
    3. Targeted disruption of Drosophila Roc1b reveals functional differences in the Roc subunit of Cullin-dependent E3 ubiquitin ligases. Donaldson TD, et al. Mol Biol Cell, 2004 Nov. PMID 15331761, Free PMC Article
    4. Occurrence of a putative SCF ubiquitin ligase complex in Drosophila. Bocca SN, et al. Biochem Biophys Res Commun, 2001 Aug 17. PMID 11500045
    5. Identifying determinants of cullin binding specificity among the three functionally different Drosophila melanogaster Roc proteins via domain swapping. Reynolds PJ, et al. PLoS One, 2008 Aug 13. PMID 18698375, Free PMC Article

    See all (48) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables NEDD8 ligase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables cullin family protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cullin family protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell population proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in lipid storage IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein neddylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein ubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of Cul3-RING ubiquitin ligase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of SCF ubiquitin ligase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    part_of cullin-RING ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    regulator of cullins 1b
    Names
    CG16988-PA
    Roc1b-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      357981..358486
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_144356.3 → NP_652613.1  regulator of cullins 1b [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_652613.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9NHX0, Q9W0R1
      Related
      FBpp0072446
      Conserved Domains (2) summary
      pfam12678
      Location:36 → 112
      zf-rbx1; RING-H2 zinc finger
      cl17238
      Location:35 → 122
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9NHX0.2 Q9NHX0

    Gene LinkOut

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