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    arg arginase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 46717, updated on 9-Dec-2024

    Summary

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    Official Symbol
    argprovided by FlyBase
    Official Full Name
    arginaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0023535
    Locus tag
    Dmel_CG18104
    See related
    AllianceGenome:FB:FBgn0023535
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Arg; CG18104; Dmel\CG18104; EG:171D11.4; EG:65F1.3
    Summary
    Predicted to enable arginase activity and manganese ion binding activity. Predicted to be involved in arginine catabolic process to ornithine. Predicted to be located in mitochondrial outer membrane. Predicted to be active in cytosol. Is expressed in embryonic/larval fat body; head; and organism. Used to study hyperargininemia. Human ortholog(s) of this gene implicated in asthma; hepatocellular carcinoma; and hyperargininemia. Orthologous to human ARG1 (arginase 1) and ARG2 (arginase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See arg in Genome Data Viewer
    Location:
    1B7-1B8; 1-0 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (509435..528028)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (403468..422061)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR44891 Neighboring gene antisense RNA:CR44892 Neighboring gene silver Neighboring gene elav noncoding regulatory RNA Neighboring gene embryonic lethal abnormal vision Neighboring gene uncharacterized protein Neighboring gene beta amyloid protein precursor-like Neighboring gene mir-4960 stem loop Neighboring gene ventral nervous system defective Neighboring gene split discs

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila arginase is produced from a nonvital gene that contains the elav locus within its third intron. Samson ML. J Biol Chem, 2000 Oct 6. PMID 10878001
    2. Mediator complex subunit Med19 binds directly GATA transcription factors and is required with Med1 for GATA-driven gene regulation in vivo. Immarigeon C, et al. J Biol Chem, 2020 Sep 25. PMID 32737196, Free PMC Article
    3. Spatiotemporal patterning of polyamines in Drosophila development. Burnette M, et al. Amino Acids, 2015 Dec. PMID 26386564
    4. GeneFizz: A web tool to compare genetic (coding/non-coding) and physical (helix/coil) segmentations of DNA sequences. Gene discovery and evolutionary perspectives. Yeramian E, et al. Nucleic Acids Res, 2003 Jul 1. PMID 12824434, Free PMC Article
    5. Epidermal Growth Factor Pathway Signaling in Drosophila Embryogenesis: Tools for Understanding Cancer. Lusk JB, et al. Cancers (Basel), 2017 Feb 7. PMID 28178204, Free PMC Article

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables arginase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables arginase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables arginase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables manganese ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in arginine catabolic process to ornithine IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in arginine catabolic process to ornithine ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in arginine metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial outer membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    arginase
    Names
    CG18104-PA
    arg-PA
    NP_524875.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      509435..528028
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_080136.3 → NP_524875.1  arginase [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524875.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O76895, Q9NHA5
      Related
      FBpp0070083
      Conserved Domains (1) summary
      cd09989
      Location:32 → 331
      Arginase; Arginase family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O76895 O76895
    Q9NHA5 Q9NHA5
    Q9W5F2 Q9W5F2

    Gene LinkOut

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