U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    ATPsynbeta ATP synthase, beta subunit [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43829, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    ATPsynbetaprovided by FlyBase
    Official Full Name
    ATP synthase, beta subunitprovided by FlyBase
    Primary source
    FLYBASE:FBgn0010217
    Locus tag
    Dmel_CG11154
    See related
    AllianceGenome:FB:FBgn0010217
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    ATP; ATP syn-beta; ATP-B; ATP-syn-B; ATP-syn-beta; ATP-synbeta; ATP5B; ATP5beta; ATP5F1B; ATPase beta; ATPase-beta; ATPasebeta; ATPB; ATPsyn; ATPsyn b; ATPsyn-b; ATPsyn-beta; beta-ATPase; CG11154; Comp V beta; complex Vbeta; dATP5B; Dmel\CG11154
    Summary
    Predicted to enable ATP binding activity and ATP hydrolysis activity. Predicted to contribute to proton-transporting ATP synthase activity, rotational mechanism. Predicted to be involved in proton motive force-driven mitochondrial ATP synthesis. Located in mitochondrion. Is expressed in several structures, including adult brain cell body rind; adult head; adult heart; adult hemolymph; and adult optic lobe. Orthologous to human ATP5F1B (ATP synthase F1 subunit beta). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See ATPsynbeta in Genome Data Viewer
    Location:
    102F6-102F6; 4-0 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 4 NC_004353.4 (1031484..1034917)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 4 NC_004353.3 (1052110..1055543)

    Chromosome 4 - NC_004353.4Genomic Context describing neighboring genes Neighboring gene Plexin A Neighboring gene antisense RNA:CR44031 Neighboring gene uncharacterized protein Neighboring gene Mitochondrial inner membrane protein MPV17 Neighboring gene Calcium/calmodulin-dependent protein kinase II Neighboring gene Zyxin Neighboring gene apolipophorin

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. The beta subunit of the Drosophila melanogaster ATP synthase: cDNA cloning, amino acid analysis and identification of the protein in adult flies. Peña P, et al. Biochem Biophys Res Commun, 1993 Sep 15. PMID 8373413
    2. Identification of a proximal promoter region critical for the expression of the beta-F1-ATPase gene during Drosophila melanogaster development. Ugalde C, et al. Mitochondrion, 2001 Oct. PMID 16120280
    3. Intron distribution in ancient paralogs supports random insertion and not random loss. Cho G, et al. J Mol Evol, 1997 Jun. PMID 9169549
    4. Analysis of the mitochondrial ATP synthase beta-subunit gene in Drosophilidae: structure, transcriptional regulatory features and developmental pattern of expression in Drosophila melanogaster. Peña P, et al. Biochem J, 1995 Dec 15. PMID 8554535, Free PMC Article
    5. The expression of heat shock protein HSP60A reveals a dynamic mitochondrial pattern in Drosophila melanogaster embryos. Baena-López LA, et al. J Proteome Res, 2008 Jul. PMID 18549261

    See all (141) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. the data from the present study revealed that ATP synthase serves important roles for male fertility during spermatogenesis by regulating germ cell maturation in Drosophila testes.
      Title: ATP synthase is required for male fertility and germ cell maturation in Drosophila testes.
    2. ATP synthase F1 subunits recruited to centromeres by CENP-A are required for male meiosis.
      Title: ATP synthase F(1) subunits recruited to centromeres by CENP-A are required for male meiosis.
    Submit: New GeneRIF Correction

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to proton-transporting ATP synthase activity, rotational mechanism IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables proton-transporting ATP synthase activity, rotational mechanism IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to proton-transporting ATP synthase activity, rotational mechanism ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in proton motive force-driven ATP synthesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proton motive force-driven ATP synthesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in proton motive force-driven mitochondrial ATP synthesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in mitochondrion HDA PubMed 
    part_of proton-transporting ATP synthase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of proton-transporting ATP synthase complex, catalytic core F(1) IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of proton-transporting ATP synthase complex, catalytic core F(1) IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of proton-transporting ATP synthase, catalytic core ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    ATP synthase, beta subunit
    Names
    ATP synthase
    ATP synthase beta
    ATP synthase beta chain
    ATP synthase beta subunit
    ATP synthase beta-subunit
    ATP synthase subunit beta
    ATP synthase subunit beta, mitochondrial
    ATP synthase subunits beta
    ATP synthase-beta
    ATPsynbeta-PA
    ATPsynbeta-PC
    ATPsynbeta-PD
    CG11154-PA
    CG11154-PC
    CG11154-PD
    F0/F1 ATP synthase beta
    F1ATP synthase
    H+-ATPase beta subunit
    beta-F1-ATPase
    complex V beta
    mitochondrial ATPsynbeta

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004353.4 Reference assembly

      Range
      1031484..1034917
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001272152.1 → NP_001259081.1  ATP synthase, beta subunit, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259081.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      L0MQ04
      Conserved Domains (4) summary
      PRK09280
      Location:44 → 507
      PRK09280; F0F1 ATP synthase subunit beta; Validated
      cd01133
      Location:114 → 393
      F1-ATPase_beta; F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a ...
      pfam00306
      Location:401 → 508
      ATP-synt_ab_C; ATP synthase alpha/beta chain, C terminal domain
      pfam02874
      Location:46 → 112
      ATP-synt_ab_N; ATP synthase alpha/beta family, beta-barrel domain

    2. NM_001297790.1 → NP_001284719.1  ATP synthase, beta subunit, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001284719.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q05825, Q9V494
      UniProtKB/TrEMBL
      X2JH42
      Conserved Domains (1) summary
      PRK09280
      Location:38 → 501
      PRK09280; F0F1 ATP synthase subunit beta; Validated

    3. NM_166808.3 → NP_726631.1  ATP synthase, beta subunit, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726631.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q05825, Q9V494
      UniProtKB/TrEMBL
      X2JH42
      Related
      FBpp0088250
      Conserved Domains (1) summary
      PRK09280
      Location:38 → 501
      PRK09280; F0F1 ATP synthase subunit beta; Validated
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    L0MQ04 L0MQ04
    Q05825.3 Q05825
    Q6W4K9 Q6W4K9
    Q6W4M9 Q6W4M9
    X2JH42 X2JH42

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous