HLH54F HLH54F [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: HLH54Fprovided by FlyBase
Official Full Name: HLH54Fprovided by FlyBase
Primary source: FLYBASE:FBgn0022740
Locus tag: Dmel_CG5005
See related: AllianceGenome:FB:FBgn0022740
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: bHLH54F; bHLHa9; CG5005; Dmel\CG5005; HLH102C; HLH54; hlh54f; HLH54F-Dm
Summary: Enables protein heterodimerization activity. Involved in positive regulation of transcription by RNA polymerase II and visceral muscle development. Predicted to be located in nucleus. Is expressed in several structures, including dorsal pharyngeal muscle primordium; embryonic/larval hypodermal muscle cell; embryonic/larval midgut; segment; and visceral muscle primordium. Human ortholog(s) of this gene implicated in coronary artery disease and ventricular septal defect. Orthologous to several human genes including MSC (musculin). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
NEW: Try the new Gene table
Try the new Transcript table

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (17757405..17760517)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (13644910..13648022)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

HLH54F mutant embryos, larvae, and adults lack all longitudinal midgut muscles, which causes defects in gut morphology and integrity.
Title: HLH54F is required for the specification and migration of longitudinal gut muscle founders from the caudal mesoderm of Drosophila.
findings on HLH54F, a basic helix-loop-helix transcription factor gene that was highly expressed in the prothoracic gland, an organ producing the insect steroid ecdysone
Title: A basic-HLH transcription factor, HLH54F, is highly expressed in the prothoracic gland in the silkworm Bombyx mori and the fruit fly Drosophila melanogaster.

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info
enables protein heterodimerization activity	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in developmental process	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in visceral muscle development	IMP Inferred from Mutant Phenotype more info	PubMed