Tm7sf3 transmembrane 7 superfamily member 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tm7sf3provided by MGI
Official Full Name: transmembrane 7 superfamily member 3provided by MGI
Primary source: MGI:MGI:1914873
See related: Ensembl:ENSMUSG00000040234 AllianceGenome:MGI:1914873
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: NARP1; 2010003B14Rik
Summary: Involved in cellular response to unfolded protein and negative regulation of programmed cell death. Predicted to be active in plasma membrane. Is expressed in several structures, including brain; cardiovascular system; genitourinary system; sensory organ; and skeleton. Orthologous to human TM7SF3 (transmembrane 7 superfamily member 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in kidney adult (RPKM 11.6), limb E14.5 (RPKM 9.9) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 G3; 6 77.7 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (146503774..146536103, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (146602276..146634605, complement)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The NF-kappaB signalling pathway and TM7SF3 contribute to liver fibrosis caused by secreted phospholipase A2 of Clonorchis sinensis.
Title: The NF-κB signalling pathway and TM7SF3 contribute to liver fibrosis caused by secreted phospholipase A2 of Clonorchis sinensis.
Data indicate that TM7SF3 plays a role in inhibition of cytokine-induced cell death/apoptosis in pancreatic beta cells and in inhibition of insulin secretion from pancreatic beta cells.
Title: An siRNA screen identifies transmembrane 7 superfamily member 3 (TM7SF3), a seven transmembrane orphan receptor, as an inhibitor of cytokine-induced death of pancreatic beta cells.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Gene trapped (1)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Tm7sf3 (e-PCR), detects polymorphism
- UniSTS:547382

D6Mit201 (e-PCR), detects polymorphism
- UniSTS:130744

D6Mit201.2 (e-PCR), detects polymorphism
- UniSTS:130745

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in cellular response to unfolded protein	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to unfolded protein	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of programmed cell death	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of programmed cell death	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of programmed cell death	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of insulin secretion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of insulin secretion	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: transmembrane 7 superfamily member 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_026281.2 → NP_080557.2 transmembrane 7 superfamily member 3 precursor

See identical proteins and their annotated locations for NP_080557.2

Status: VALIDATED

Source sequence(s)

AC124128, AK010720

Consensus CDS

CCDS20699.1

UniProtKB/Swiss-Prot

Q3TBQ2, Q3U3Q6, Q4F873, Q6PES5, Q9CRG1

UniProtKB/TrEMBL

A0A0R4J0K4

Related

ENSMUSP00000045650.10, ENSMUST00000037709.16

Conserved Domains (1) summary

pfam13886
Location:291 → 498

DUF4203; Domain of unknown function (DUF4203)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000072.7 Reference GRCm39 C57BL/6J

Range

146503774..146536103 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030255567.1 → XP_030111427.1 transmembrane 7 superfamily member 3 isoform X1

Conserved Domains (1) summary

pfam13886
Location:79 → 286

DUF4203; Domain of unknown function (DUF4203)
XM_036152277.1 → XP_036008170.1 transmembrane 7 superfamily member 3 isoform X1

Conserved Domains (1) summary

pfam13886
Location:79 → 286

DUF4203; Domain of unknown function (DUF4203)