Acsf2 acyl-CoA synthetase family member 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Acsf2provided by MGI
Official Full Name: acyl-CoA synthetase family member 2provided by MGI
Primary source: MGI:MGI:2388287
See related: Ensembl:ENSMUSG00000076435 AllianceGenome:MGI:2388287
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Predicted to enable medium-chain fatty acid-CoA ligase activity. Predicted to be involved in fatty acid metabolic process. Located in mitochondrion. Is expressed in several structures, including connective tissue; gonad; gut gland; immune system; and nervous system. Orthologous to human ACSF2 (acyl-CoA synthetase family member 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in adrenal adult (RPKM 67.2), colon adult (RPKM 33.0) and 21 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 D; 11 58.9 cM

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (94447928..94492822, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (94557102..94602139, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ACSF2 and lysine lactylation contribute to renal tubule injury in diabetes.
Title: ACSF2 and lysine lactylation contribute to renal tubule injury in diabetes.
Inhibition of ACSF2 protects against renal ischemia/reperfusion injury via mediating mitophagy in proximal tubular cells.
Title: Inhibition of ACSF2 protects against renal ischemia/reperfusion injury via mediating mitophagy in proximal tubular cells.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (4)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Chad (e-PCR), detects polymorphism
- UniSTS:141330

D11Mit288 (e-PCR), detects polymorphism
- UniSTS:126495

D11Dcr17 (e-PCR), detects polymorphism
- UniSTS:507460

U96626 (e-PCR)
- UniSTS:160143

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables medium-chain fatty acid-CoA ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables medium-chain fatty acid-CoA ligase activity	ISO Inferred from Sequence Orthology more info
enables medium-chain fatty acid-CoA ligase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in fatty acid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in fatty acid metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in mitochondrion	HDA more info	PubMed

General protein information

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Preferred Names: medium-chain acyl-CoA ligase ACSF2, mitochondrial

Names: acyl-CoA synthetase family member 2, mitochondrial

NP_722502.1

EC 6.2.1.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.