Ubl4a ubiquitin-like 4A [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ubl4aprovided by MGI
Official Full Name: ubiquitin-like 4Aprovided by MGI
Primary source: MGI:MGI:95049
See related: Ensembl:ENSMUSG00000015290 AllianceGenome:MGI:95049
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gdx; Ubl4; DXS254E; DXS254Eh; DXHXS254E
Summary: Predicted to enable protein-folding chaperone binding activity. Predicted to be involved in establishment of protein localization to membrane; regulation of protein stability; and ubiquitin-dependent protein catabolic process. Predicted to be located in cytosol; membrane; and nucleoplasm. Predicted to be part of BAT3 complex. Is expressed in olfactory cortex ventricular layer; olfactory epithelium; and telencephalon ventricular layer. Orthologous to human UBL4A (ubiquitin like 4A). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in heart adult (RPKM 25.5), kidney adult (RPKM 22.3) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: X A7.3; X 38.0 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	X	NC_000086.8 (73409324..73412154, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	X	NC_000086.7 (74365718..74368548, complement)

Chromosome X - NC_000086.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Ubl4A is critical for mitochondrial fusion process under nutrient deprivation stress.
Title: Ubl4A is critical for mitochondrial fusion process under nutrient deprivation stress.
a novel positive feedback regulation of UBL4A in innate immune response combating virus invasion by enhancing the K63-linked ubiquitination of TRAF6.
Title: UBL4A Augments Innate Immunity by Promoting the K63-Linked Ubiquitination of TRAF6.
These findings suggested that GdX functions as an important regulator of Th1 or Th17 and Treg cell balance during the inflammatory responses.
Title: GdX/UBL4A-knockout mice resist collagen-induced arthritis by balancing the population of T(h)1/T(h)17 and regulatory T cells.
This study provides a mechanism by which NF-kappaB signaling is positively regulated by an adaptor protein GdX in dendritic cells or macrophages to maintain the innate immune response.
Title: Absence of GdX/UBL4A Protects against Inflammatory Diseases by Regulating NF-кB Signaling in Macrophages and Dendritic Cells.
The single point mutation of an aspartic acid to alanine (D122A) in the Ubl4A C-terminus abolishes its ability to bind the Arp2/3 complex. This mutation also destabilizes Ubl4A proteins susceptible to protease degradation.
Title: The C-terminus of Ubl4A is critical for pro-death activity and association with the Arp2/3 complex.
The results uncovered GdX as a novel regulator in bone development and a potential candidate gene for skeletal dysplasias.
Title: GdX/UBL4A null mice exhibit mild kyphosis and scoliosis accompanied by dysregulation of osteoblastogenesis and chondrogenesis.
Ubl4A has a role in fibroblast and macrophage migration-associated pathophysiological processes
Title: Deficiency in ubiquitin-like protein Ubl4A impairs migration of fibroblasts and macrophages.
ubiquitin-like protein 4A (Ubl4A) plays a crucial role in insulin-induced Akt plasma membrane translocation.
Title: Ubl4A is required for insulin-induced Akt plasma membrane translocation through promotion of Arp2/3-dependent actin branching.
Data indicate that the BAGS domain of BAG6 (Bcl-2-associated athanogene 6) interacts with the C-terminal domain of Ubl4a (ubiquitin-like protein 4a).
Title: Structure of a BAG6 (Bcl-2-associated athanogene 6)-Ubl4a (ubiquitin-like protein 4a) complex reveals a novel binding interface that functions in tail-anchored protein biogenesis.
GdX converts TC45, a nonspecific phosphatase, into a STAT3-specific phosphatase by bridging an association between TC45 and STAT3
Title: GdX/UBL4A specifically stabilizes the TC45/STAT3 association and promotes dephosphorylation of STAT3 to repress tumorigenesis.

Submit: New GeneRIF Correction See all GeneRIFs (12)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation

General gene information

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Markers

Slc10a3 (e-PCR), detects polymorphism
- UniSTS:527538

Readthrough Gm44504

Readthrough gene: Gm44504, Included gene: Slc10a3

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein-folding chaperone binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein-folding chaperone binding	IEA Inferred from Electronic Annotation more info
enables protein-folding chaperone binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in post-translational protein targeting to endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in post-translational protein targeting to endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein stability	ISO Inferred from Sequence Orthology more info
involved_in tail-anchored membrane protein insertion into ER membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in tail-anchored membrane protein insertion into ER membrane	ISO Inferred from Sequence Orthology more info
involved_in tail-anchored membrane protein insertion into ER membrane	ISS Inferred from Sequence or Structural Similarity more info
involved_in ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of BAT3 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of BAT3 complex	ISO Inferred from Sequence Orthology more info
part_of BAT3 complex	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	NAS Non-traceable Author Statement more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ubiquitin-like protein 4A

Names: housekeeping protein DXS254E; ubiquitin-like 4; ubiquitin-like protein GDX

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_145405.2 → NP_663380.1 ubiquitin-like protein 4A

See identical proteins and their annotated locations for NP_663380.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer, protein-coding transcript.

Source sequence(s)

AK048689, BM900115, BM932729, BY273712

Consensus CDS

CCDS30230.1

UniProtKB/Swiss-Prot

P21126

UniProtKB/TrEMBL

B2M0S0, Q3UK94

Related

ENSMUSP00000120461.2, ENSMUST00000155676.8

Conserved Domains (2) summary

cd01807
Location:1 → 72

Ubl_UBL4A_like; ubiquitin-like (Ubl) domain found in ubiquitin-like proteins UBL4A and similar proteins

pfam17840
Location:96 → 142

Tugs; Tethering Ubl4a to BAGS domain

RNA

NR_045779.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks a coding exon compared to variant 1, that causes a frameshift. The resulting transcript is a candidate for nonsense-mediated mRNA decay (NMD), so it likely does not encode a protein.

Source sequence(s)

AK048689, BM900115, BM932729, BY107969, BY273712

Related

ENSMUST00000126117.2