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    Paox polyamine oxidase (exo-N4-amino) [ Mus musculus (house mouse) ]

    Gene ID: 212503, updated on 9-Dec-2024

    Summary

    Official Symbol
    Paoxprovided by MGI
    Official Full Name
    polyamine oxidase (exo-N4-amino)provided by MGI
    Primary source
    MGI:MGI:1916983
    See related
    Ensembl:ENSMUSG00000025464 AllianceGenome:MGI:1916983
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Pao; 2410012F02Rik
    Summary
    Enables polyamine oxidase activity. Acts upstream of or within polyamine catabolic process. Predicted to be located in peroxisomal matrix. Predicted to be active in cytoplasm. Is expressed in several structures, including central nervous system; genitourinary system; gut; hemolymphoid system gland; and integumental system. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma. Orthologous to human PAOX (polyamine oxidase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in liver adult (RPKM 11.4), ovary adult (RPKM 8.2) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Paox in Genome Data Viewer
    Location:
    7 F4; 7 85.14 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (139693182..139714249)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (140115735..140134334)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene proline-rich acidic protein 1 Neighboring gene fucose mutarotase Neighboring gene enoyl Coenzyme A hydratase, short chain, 1, mitochondrial Neighboring gene STARR-positive B cell enhancer ABC_E1747 Neighboring gene mitochondrial ribosome-associated GTPase 1 Neighboring gene shadow of prion protein Neighboring gene olfactory receptor family 6 subfamily AE member 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (2) 

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    is_active_in cytoplasm  
    located_in peroxisomal matrix  
    located_in peroxisomal matrix  

    General protein information

    Preferred Names
    peroxisomal N(1)-acetyl-spermine/spermidine oxidase
    Names
    exo-N4-amino
    peroxisomal N1-acetyl-spermine/spermidine oxidase
    NP_001333654.1
    NP_722478.2
    XP_006536229.4
    XP_006536230.1
    XP_006536231.1
    XP_011248141.1
    XP_011248143.3
    XP_017177591.1
    XP_017177592.1
    XP_030098194.1
    XP_036008771.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001346725.2NP_001333654.1  peroxisomal N(1)-acetyl-spermine/spermidine oxidase isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC109205
      Consensus CDS
      CCDS85452.1
      UniProtKB/TrEMBL
      Q3TXR6
      Related
      ENSMUSP00000095580.4, ENSMUST00000097967.4
    2. NM_153783.4NP_722478.2  peroxisomal N(1)-acetyl-spermine/spermidine oxidase isoform 1

      See identical proteins and their annotated locations for NP_722478.2

      Status: VALIDATED

      Source sequence(s)
      AC109205
      Consensus CDS
      CCDS21965.1
      UniProtKB/Swiss-Prot
      Q8C0L6, Q8K254
      UniProtKB/TrEMBL
      Q4GX45
      Related
      ENSMUSP00000026537.6, ENSMUST00000026537.13
      Conserved Domains (2) summary
      PLN02568
      Location:6490
      PLN02568; polyamine oxidase
      pfam13450
      Location:1079
      NAD_binding_8; NAD(P)-binding Rossmann-like domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      139693182..139714249
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011249839.4XP_011248141.1  peroxisomal N(1)-acetyl-spermine/spermidine oxidase isoform X2

      See identical proteins and their annotated locations for XP_011248141.1

      UniProtKB/TrEMBL
      Q4GX45
      Conserved Domains (1) summary
      PLN02568
      Location:3440
      PLN02568; polyamine oxidase
    2. XM_030242334.2XP_030098194.1  peroxisomal N(1)-acetyl-spermine/spermidine oxidase isoform X5

      Conserved Domains (1) summary
      PLN02568
      Location:42386
      PLN02568; polyamine oxidase
    3. XM_011249841.4XP_011248143.3  peroxisomal N(1)-acetyl-spermine/spermidine oxidase isoform X6

      Conserved Domains (1) summary
      PLN02568
      Location:105380
      PLN02568; polyamine oxidase
    4. XM_017322103.3XP_017177592.1  peroxisomal N(1)-acetyl-spermine/spermidine oxidase isoform X5

      Conserved Domains (1) summary
      PLN02568
      Location:42386
      PLN02568; polyamine oxidase
    5. XM_006536166.4XP_006536229.4  peroxisomal N(1)-acetyl-spermine/spermidine oxidase isoform X1

      UniProtKB/TrEMBL
      Q4GX45
      Conserved Domains (1) summary
      PLN02568
      Location:141485
      PLN02568; polyamine oxidase
    6. XM_036152878.1XP_036008771.1  peroxisomal N(1)-acetyl-spermine/spermidine oxidase isoform X2

      UniProtKB/TrEMBL
      Q4GX45
      Conserved Domains (1) summary
      PLN02568
      Location:3440
      PLN02568; polyamine oxidase
    7. XM_006536167.5XP_006536230.1  peroxisomal N(1)-acetyl-spermine/spermidine oxidase isoform X4

      Conserved Domains (1) summary
      PLN02568
      Location:6323
      PLN02568; polyamine oxidase
    8. XM_017322102.3XP_017177591.1  peroxisomal N(1)-acetyl-spermine/spermidine oxidase isoform X3

      Conserved Domains (1) summary
      PLN02568
      Location:6323
      PLN02568; polyamine oxidase
    9. XM_006536168.4XP_006536231.1  peroxisomal N(1)-acetyl-spermine/spermidine oxidase isoform X5

      Conserved Domains (1) summary
      PLN02568
      Location:42386
      PLN02568; polyamine oxidase

    RNA

    1. XR_001785516.3 RNA Sequence

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