Mrgpra2b MAS-related GPR, member A2B [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mrgpra2bprovided by MGI
Official Full Name: MAS-related GPR, member A2Bprovided by MGI
Primary source: MGI:MGI:3033098
See related: Ensembl:ENSMUSG00000096719 AllianceGenome:MGI:3033098
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: MrgA2; Mrgpra2
Summary: Predicted to enable G protein-coupled receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to be active in plasma membrane. Orthologous to human MRGPRX3 (MAS related GPR family member X3) and MRGPRX4 (MAS related GPR family member X4). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in liver E18 (RPKM 3.9), testis adult (RPKM 1.2) and 4 other tissues See more
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Genomic context

Location:: 7 B3; 7 30.86 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (47113555..47139330, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (47463807..47489582, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Keratinocyte-derived defensins activate neutrophil-specific receptors Mrgpra2a/b to prevent skin dysbiosis and bacterial infection.
Title: Keratinocyte-derived defensins activate neutrophil-specific receptors Mrgpra2a/b to prevent skin dysbiosis and bacterial infection.
Ultra-high doses did not influence the ACE2/AT2R/Mas axis and promoted renal injury with increased renal ERK1/2 activation and exaggerated fibronectin expression in db/db mice. Our study demonstrates dose-related effects of candesartan in diabetic nephropathy: intermediate-high dose candesartan is renoprotective, whereas ultra-high dose candesartan induces renal damage.
Title: Differential renal effects of candesartan at high and ultra-high doses in diabetic mice-potential role of the ACE2/AT2R/Mas axis.
data suggest that members of the Mrgpr family, in particular MrgprC11, may constitute an endogenous inhibitory mechanism for regulating persistent pain in mice
Title: Mas-related G-protein-coupled receptors inhibit pathological pain in mice.
Mas deficiency in FVB/N mice leads to dramatic changes in glucose and lipid metabolisms, inducing a metabolic syndrome-like state.
Title: Mas deficiency in FVB/N mice produces marked changes in lipid and glycemic metabolism.
Deletion of the Mas protooncogene abolishes the binding of Ang-(1-7) to mouse kidneys. Mas is a functional receptor for Ang-(1-7)
Title: Angiotensin-(1-7) is an endogenous ligand for the G protein-coupled receptor Mas.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (1)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: mas-related G-protein coupled receptor member A2B

Names: G protein-coupled receptor MrgA2; MAS-related GPR, member A2; Mas-related gene A2; mas-related G-protein coupled receptor member A2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001382001.1 → NP_001368930.1 mas-related G-protein coupled receptor member A2B isoform 1

Status: VALIDATED

Source sequence(s)

AC138678

UniProtKB/TrEMBL

Q3U1A9

Conserved Domains (1) summary

cd15105
Location:41 → 316

7tmA_MrgprA; mas-related G protein-coupled receptor subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors
NM_153101.3 → NP_694741.2 mas-related G-protein coupled receptor member A2B isoform 2

Status: VALIDATED

Source sequence(s)

AY042192, DY243808, DY245072

Consensus CDS

CCDS21296.2

UniProtKB/TrEMBL

E9QNZ7, Q3U1A9

Related

ENSMUSP00000113310.3, ENSMUST00000119798.3

Conserved Domains (1) summary

cd15105
Location:40 → 315

7tmA_MrgprA; mas-related G protein-coupled receptor subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors