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    Rab8a RAB8A, member RAS oncogene family [ Mus musculus (house mouse) ]

    Gene ID: 17274, updated on 17-Dec-2024

    Summary

    Official Symbol
    Rab8aprovided by MGI
    Official Full Name
    RAB8A, member RAS oncogene familyprovided by MGI
    Primary source
    MGI:MGI:96960
    See related
    Ensembl:ENSMUSG00000003037 AllianceGenome:MGI:96960
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mel
    Summary
    Predicted to enable several functions, including enzyme binding activity; guanyl ribonucleotide binding activity; and myosin V binding activity. Involved in cilium assembly and protein localization to cilium. Located in several cellular components, including ciliary base; ciliary membrane; and cytoplasmic vesicle. Is expressed in brain; liver; neural retina; and small intestine. Orthologous to human RAB8A (RAB8A, member RAS oncogene family). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in large intestine adult (RPKM 57.7), duodenum adult (RPKM 54.3) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Rab8a in Genome Data Viewer
    Location:
    8 B3.3; 8 34.84 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (72915044..72935210)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (72161200..72181366)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 39196 Neighboring gene STARR-positive B cell enhancer ABC_E1371 Neighboring gene tropomyosin 4 Neighboring gene STARR-positive B cell enhancer ABC_E8245 Neighboring gene STARR-positive B cell enhancer ABC_E243 Neighboring gene STARR-positive B cell enhancer ABC_E11387 Neighboring gene STARR-positive B cell enhancer ABC_E8246 Neighboring gene hematopoietic SH2 domain containing Neighboring gene calcium and integrin binding family member 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (3)  1 citation

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GDP binding  
    enables GDP binding  
    enables GTP binding  
    enables GTP binding  
    enables GTPase activity  
    enables GTPase activity  
    enables GTPase activity  
    enables myosin V binding  
    enables myosin V binding  
    enables protein binding PubMed 
    enables protein kinase binding  
    enables protein tyrosine kinase binding  
    enables protein tyrosine kinase binding  
    enables small GTPase binding  
    Items 1 - 25 of 33
    Process Evidence Code Pubs
    involved_in Golgi organization  
    involved_in Golgi organization  
    involved_in Golgi vesicle fusion to target membrane  
    involved_in Golgi vesicle fusion to target membrane  
    involved_in autophagy  
    involved_in axonogenesis  
    involved_in axonogenesis  
    involved_in cellular response to insulin stimulus  
    involved_in cellular response to insulin stimulus  
    involved_in cilium assembly  
    involved_in cilium assembly PubMed 
    involved_in cilium assembly  
    involved_in cilium assembly  
    involved_in endocytic recycling  
    involved_in exocytosis  
    involved_in neurotransmitter receptor transport to postsynaptic membrane  
    involved_in neurotransmitter receptor transport to postsynaptic membrane  
    involved_in neurotransmitter receptor transport, endosome to postsynaptic membrane  
    involved_in neurotransmitter receptor transport, endosome to postsynaptic membrane  
    involved_in protein localization to cilium PubMed 
    involved_in protein localization to plasma membrane  
    involved_in protein localization to plasma membrane  
    involved_in regulation of autophagy  
    involved_in regulation of autophagy  
    involved_in regulation of long-term neuronal synaptic plasticity  
    involved_in regulation of long-term neuronal synaptic plasticity  
    involved_in regulation of protein localization  
    involved_in regulation of protein transport  
    involved_in regulation of protein transport  
    involved_in vesicle docking involved in exocytosis  
    involved_in vesicle docking involved in exocytosis  
    involved_in vesicle-mediated transport in synapse  
    involved_in vesicle-mediated transport in synapse  
    Items 1 - 25 of 33
    Items 1 - 20 of 45
    Component Evidence Code Pubs
    located_in Golgi apparatus  
    located_in Golgi apparatus  
    located_in centriole  
    located_in centrosome PubMed 
    located_in centrosome  
    located_in ciliary basal body PubMed 
    located_in ciliary base PubMed 
    located_in ciliary membrane PubMed 
    located_in cilium PubMed 
    located_in cilium PubMed 
    colocalizes_with cilium  
    located_in cilium PubMed 
    colocalizes_with cilium  
    located_in cytoplasmic vesicle  
    located_in cytoplasmic vesicle membrane  
    located_in dendrite  
    located_in dendrite  
    is_active_in dendritic spine  
    located_in dendritic spine  
    is_active_in endosome  
    located_in endosome membrane  
    located_in endosome membrane  
    located_in glutamatergic synapse  
    is_active_in glutamatergic synapse  
    located_in lysosome  
    located_in midbody  
    located_in midbody  
    located_in neuron projection PubMed 
    located_in neuronal cell body  
    located_in neuronal cell body  
    located_in non-motile cilium PubMed 
    located_in non-motile cilium  
    located_in phagocytic vesicle  
    located_in phagocytic vesicle  
    located_in phagocytic vesicle membrane  
    is_active_in plasma membrane  
    located_in plasma membrane PubMed 
    located_in postsynaptic density  
    located_in recycling endosome PubMed 
    located_in recycling endosome membrane  
    located_in recycling endosome membrane  
    is_active_in synapse  
    is_active_in synaptic vesicle  
    is_active_in trans-Golgi network transport vesicle  
    located_in trans-Golgi network transport vesicle PubMed 
    Items 1 - 20 of 45

    General protein information

    Preferred Names
    ras-related protein Rab-8A
    Names
    cell line NK14 derived transforming oncogene
    oncogene c-mel
    NP_075615.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_023126.2NP_075615.2  ras-related protein Rab-8A

      See identical proteins and their annotated locations for NP_075615.2

      Status: VALIDATED

      Source sequence(s)
      AK009259, AK010862, AK076048, BY279480, BY700504
      Consensus CDS
      CCDS22409.1
      UniProtKB/Swiss-Prot
      P55258, Q8VCF6
      UniProtKB/TrEMBL
      Q0PD50, Q3UHW5
      Related
      ENSMUSP00000003121.9, ENSMUST00000003121.9
      Conserved Domains (1) summary
      cd01867
      Location:6172
      Rab8_Rab10_Rab13_like; Rab GTPase families 8, 10, 13 (Rab8, Rab10, Rab13)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      72915044..72935210
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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