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    Jcad junctional cadherin 5 associated [ Mus musculus (house mouse) ]

    Gene ID: 240185, updated on 9-Dec-2024

    Summary

    Official Symbol
    Jcadprovided by MGI
    Official Full Name
    junctional cadherin 5 associatedprovided by MGI
    Primary source
    MGI:MGI:2685174
    See related
    Ensembl:ENSMUSG00000033960 AllianceGenome:MGI:2685174
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm328; mKIAA1462; 1110056P05Rik; 9430020K01Rik
    Summary
    Involved in positive regulation of sprouting angiogenesis. Located in cell-cell junction. Is expressed in meninges; tail mesenchyme; and vertebral axis musculature. Orthologous to human JCAD (junctional cadherin 5 associated). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in lung adult (RPKM 23.0), cortex adult (RPKM 11.1) and 20 other tissues See more
    Orthologs
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    Genomic context

    See Jcad in Genome Data Viewer
    Location:
    18 A1; 18 3.01 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (4590775..4682869)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (4590792..4682869)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene protein arginine N-methyltransferase 8 pseudogene Neighboring gene STARR-seq mESC enhancer starr_43680 Neighboring gene predicted gene, 41658 Neighboring gene STARR-seq mESC enhancer starr_43681 Neighboring gene STARR-seq mESC enhancer starr_43682 Neighboring gene STARR-seq mESC enhancer starr_43683 Neighboring gene predicted gene 5047 Neighboring gene STARR-positive B cell enhancer ABC_E7570 Neighboring gene STARR-seq mESC enhancer starr_43684 Neighboring gene predicted gene 10556 Neighboring gene predicted gene, 34269

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (2)  1 citation

    Interactions

    General gene information

    Clone Names

    • KIAA1462

    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    is_active_in adherens junction  
    located_in adherens junction  
    located_in adherens junction  
    located_in cell junction PubMed 
    located_in cell-cell junction PubMed 
    located_in perinuclear region of cytoplasm  
    located_in perinuclear region of cytoplasm  
    is_active_in ruffle membrane  
    located_in ruffle membrane  
    located_in ruffle membrane  

    General protein information

    Preferred Names
    junctional cadherin 5-associated protein
    Names
    junctional protein associated with coronary artery disease

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081963.1NP_001075432.1  junctional cadherin 5-associated protein

      See identical proteins and their annotated locations for NP_001075432.1

      Status: VALIDATED

      Source sequence(s)
      AC147227, AK220394, BU757028
      Consensus CDS
      CCDS37719.1
      UniProtKB/Swiss-Prot
      Q5DTX6
      UniProtKB/TrEMBL
      B7ZN02
      Related
      ENSMUSP00000038613.6, ENSMUST00000037029.7
      Conserved Domains (1) summary
      pfam15351
      Location:11309
      JCAD; Junctional protein associated with coronary artery disease

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      4590775..4682869
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006525904.4XP_006525967.1  junctional cadherin 5-associated protein isoform X1

      See identical proteins and their annotated locations for XP_006525967.1

      UniProtKB/Swiss-Prot
      Q5DTX6
      UniProtKB/TrEMBL
      B7ZN02
      Related
      ENSMUSP00000157313.2, ENSMUST00000234153.2
      Conserved Domains (1) summary
      pfam15351
      Location:11309
      JCAD; Junctional protein associated with coronary artery disease
    2. XM_006525903.4XP_006525966.1  junctional cadherin 5-associated protein isoform X1

      See identical proteins and their annotated locations for XP_006525966.1

      UniProtKB/Swiss-Prot
      Q5DTX6
      UniProtKB/TrEMBL
      B7ZN02
      Conserved Domains (1) summary
      pfam15351
      Location:11309
      JCAD; Junctional protein associated with coronary artery disease
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