Slain1 SLAIN motif family, member 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Slain1provided by MGI
Official Full Name: SLAIN motif family, member 1provided by MGI
Primary source: MGI:MGI:2145578
See related: Ensembl:ENSMUSG00000055717 AllianceGenome:MGI:2145578
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 9630044O09Rik
Summary: Predicted to be involved in cytoplasmic microtubule organization; microtubule nucleation; and positive regulation of microtubule polymerization. Predicted to be located in cytoplasm and cytoskeleton. Predicted to colocalize with microtubule plus-end. Is expressed in several structures, including brain; immune system; neural ectoderm; sensory organ; and somite. Orthologous to human SLAIN1 (SLAIN motif family member 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in CNS E18 (RPKM 21.4), whole brain E14.5 (RPKM 19.0) and 18 other tissues See more
Orthologs: human all
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Genomic context

Location:: 14 E2.3; 14 52.75 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (103887664..103942343)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (103650228..103704907)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SLAIN1 is highly enriched in brain and expressed throughout brain development.
Title: Microtubule plus-end tracking proteins SLAIN1/2 and ch-TOG promote axonal development.
Data suggest that Slain1 may play a role in the development of the nervous system, as well as in the morphogenesis of several embryonic structures.
Title: Expression from a betageo gene trap in the Slain1 gene locus is predominantly associated with the developing nervous system.
Expressed at the stem cell and epiblast stages of embryonic stem cell differentiation and in the epiblast, nervous system, tailbud and somites of the developing mouse embryo.
Title: Transcriptional profiling of mouse and human ES cells identifies SLAIN1, a novel stem cell gene.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Gene trapped (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH124531 (e-PCR)
- UniSTS:161353

AW742596 (e-PCR)
- UniSTS:209048

Slain1 (e-PCR), detects polymorphism
- UniSTS:496547

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in cytoplasmic microtubule organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in microtubule nucleation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of microtubule polymerization	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
colocalizes_with microtubule plus-end	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: SLAIN motif-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.