twe twine [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: tweprovided by FlyBase
Official Full Name: twineprovided by FlyBase
Primary source: FLYBASE:FBgn0002673
Locus tag: Dmel_CG4965
See related: AllianceGenome:FB:FBgn0002673
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: BG:DS02740.1; cdc25; Cdc25; CG4965; Dmel\CG4965; l(2)35Fh; mat(2)syn-A; mat(2)synHB5; mat(2)syn[HB5]; Twe; TWINE; twn
Summary: Predicted to enable protein tyrosine phosphatase activity. Involved in several processes, including male meiotic nuclear division; meiotic nuclear membrane disassembly; and regulation of syncytial blastoderm mitotic cell cycle. Located in nucleus and spindle. Is expressed in several structures, including germline cell; primary spermatocyte cyst; and testis. Human ortholog(s) of this gene implicated in autosomal recessive polycystic kidney disease; cervical cancer; endometrial cancer; prostate cancer; and urinary bladder cancer. Orthologous to several human genes including CDC25A (cell division cycle 25A). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 35F1-35F1; 2-52 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (16259414..16261877, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (16259414..16261877, complement)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Twine protein dynamics in drosophila embryo is controlled by PpV.
Title: Fluorescence fluctuation analysis reveals PpV dependent Cdc25 protein dynamics in living embryos.
Posttranslational control of Twine degradation ensures that the proper number of mitoses precede the midblastula transition.
Title: Posttranslational control of Cdc25 degradation terminates Drosophila's early cell-cycle program.
developmentally regulated destruction of Twine protein is a critical switch that contributes to the cell-cycle change at the midblastula transition
Title: Mechanism and regulation of Cdc25/Twine protein destruction in embryonic cell-cycle remodeling.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables protein tyrosine phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein tyrosine phosphatase activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine phosphatase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in G2/M transition of mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in embryonic pattern specification	HMP more info	PubMed
involved_in male meiotic nuclear division	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in meiotic nuclear membrane disassembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of G2/M transition of mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of G2/MI transition of meiotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cell cycle G2/M phase transition	IEA Inferred from Electronic Annotation more info
involved_in protein dephosphorylation	IEA Inferred from Electronic Annotation more info
involved_in regulation of meiotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of syncytial blastoderm mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in spermatogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in spindle	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: twine

Names: CG4965-PA; CG4965-PB; CG4965-PC; CG4965-PD; twe-PA; twe-PB; twe-PC; twe-PD

NP_001260491.1

EC 3.1.3.48

NP_001260492.1

EC 3.1.3.48

NP_001260493.1

EC 3.1.3.48

NP_476633.1

EC 3.1.3.48

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033779.5 Reference assembly

Range

16259414..16261877 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_057285.4 → NP_476633.1 twine, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_476633.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q03019, Q9V454

UniProtKB/TrEMBL

M9PBC2

Related

FBpp0080412

Conserved Domains (1) summary

cd01530
Location:243 → 363

Cdc25; Cdc25 phosphatases are members of the Rhodanese Homology Domain superfamily. They activate the cell division kinases throughout the cell cycle progression. Cdc25 phosphatases dephosphorylate phosphotyrosine and phosphothreonine residues, in order to ...
NM_001273563.1 → NP_001260492.1 twine, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001260492.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q03019, Q9V454

UniProtKB/TrEMBL

M9PBC2

Conserved Domains (1) summary

cd01530
Location:243 → 363

Cdc25; Cdc25 phosphatases are members of the Rhodanese Homology Domain superfamily. They activate the cell division kinases throughout the cell cycle progression. Cdc25 phosphatases dephosphorylate phosphotyrosine and phosphothreonine residues, in order to ...
NM_001273564.2 → NP_001260493.1 twine, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001260493.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q03019, Q9V454

UniProtKB/TrEMBL

M9PBC2

Conserved Domains (1) summary

cd01530
Location:243 → 363

Cdc25; Cdc25 phosphatases are members of the Rhodanese Homology Domain superfamily. They activate the cell division kinases throughout the cell cycle progression. Cdc25 phosphatases dephosphorylate phosphotyrosine and phosphothreonine residues, in order to ...
NM_001273562.2 → NP_001260491.1 twine, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001260491.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q03019, Q9V454

UniProtKB/TrEMBL

M9PBC2

Conserved Domains (1) summary

cd01530
Location:243 → 363

Cdc25; Cdc25 phosphatases are members of the Rhodanese Homology Domain superfamily. They activate the cell division kinases throughout the cell cycle progression. Cdc25 phosphatases dephosphorylate phosphotyrosine and phosphothreonine residues, in order to ...