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    Slip1 SLo interacting protein 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43809, updated on 17-Dec-2024

    Summary

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    Official Symbol
    Slip1provided by FlyBase
    Official Full Name
    SLo interacting protein 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0024728
    Locus tag
    Dmel_CG1783
    See related
    AllianceGenome:FB:FBgn0024728
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG1783; Dmel\CG1783; dSLIP1
    Summary
    Enables potassium channel regulator activity. Is expressed in organism. Orthologous to several human genes including PDZRN4 (PDZ domain containing ring finger 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Slip1 in Genome Data Viewer
    Location:
    102D4-102D4; 4-0 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 4 NC_004353.4 (663621..669884)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 4 NC_004353.3 (684247..690510)

    Chromosome 4 - NC_004353.4Genomic Context describing neighboring genes Neighboring gene gawky Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene myoglianin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. dSLo interacting protein 1, a novel protein that interacts with large-conductance calcium-activated potassium channels. Xia Xm, et al. J Neurosci, 1998 Apr 1. PMID 9502797, Free PMC Article
    2. Nucleotide variation along the Drosophila melanogaster fourth chromosome. Wang W, et al. Science, 2002 Jan 4. PMID 11778050
    3. High-resolution mapping of the Drosophila fourth chromosome using site-directed terminal deficiencies. Sousa-Neves R, et al. Genetics, 2005 May. PMID 15466427, Free PMC Article
    4. Blue light induces a neuroprotective gene expression program in Drosophila photoreceptors. Hall H, et al. BMC Neurosci, 2018 Jul 20. PMID 30029619, Free PMC Article
    5. Molecular mapping of deletion breakpoints on chromosome 4 of Drosophila melanogaster. Podemski L, et al. Chromosoma, 2004 Jun. PMID 15185094

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    mobile_element

    • Loc: 667078-667195 mobile_element_type = transposon:INE-1{}1944
    • Loc: 667816-667929 mobile_element_type = transposon:INE-1{}1945

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables potassium channel regulator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    SLo interacting protein 1
    Names
    CG1783-PA
    CG1783-PB
    CG1783-PC
    Slip1-PA
    Slip1-PB
    Slip1-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004353.4 Reference assembly

      Range
      663621..669884
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_143676.2 → NP_651933.1  SLo interacting protein 1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651933.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8MR31, Q8STH5, Q9V4F2
      UniProtKB/TrEMBL
      F0JAN0
      Related
      FBpp0088159
      Conserved Domains (2) summary
      smart00228
      Location:11 → 47
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:219 → 276
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

    2. NM_001272138.1 → NP_001259067.1  SLo interacting protein 1, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259067.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      L0MN84
      Conserved Domains (2) summary
      smart00228
      Location:11 → 47
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:219 → 276
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

    3. NM_001272137.1 → NP_001259066.1  SLo interacting protein 1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259066.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      F0JAN0, L0MPY6
      Conserved Domains (1) summary
      smart00228
      Location:11 → 47
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    L0MN84 L0MN84
    L0MPY6 L0MPY6
    Q8MR31.2 Q8MR31

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