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    RanBP3 Ran binding protein 3 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42804, updated on 27-Dec-2024

    Summary

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    Official Symbol
    RanBP3provided by FlyBase
    Official Full Name
    Ran binding protein 3provided by FlyBase
    Primary source
    FLYBASE:FBgn0039110
    Locus tag
    Dmel_CG10225
    See related
    AllianceGenome:FB:FBgn0039110
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG10225; Dmel\CG10225; GC10225
    Summary
    Involved in negative regulation of canonical Wnt signaling pathway and protein export from nucleus. Is expressed in organism. Orthologous to human RANBP3 (RAN binding protein 3) and RANBP3L (RAN binding protein 3 like). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See RanBP3 in Genome Data Viewer
    Location:
    95B1-95B1; 3-80 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (23750937..23752834, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (19576659..19578556, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Regulatory particle non-ATPase 9 Neighboring gene HMG Coenzyme A reductase Neighboring gene antisense RNA:CR46091 Neighboring gene Regulatory particle triple-A ATPase 5 Neighboring gene HMG-coA reductase degradation 3 Neighboring gene Protein tyrosine phosphatase, mitochondrial 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. RanBP3 enhances nuclear export of active (beta)-catenin independently of CRM1. Hendriksen J, et al. J Cell Biol, 2005 Dec 5. PMID 16314428, Free PMC Article
    2. Distinct functions of the Drosophila Nup153 and Nup214 FG domains in nuclear protein transport. Sabri N, et al. J Cell Biol, 2007 Aug 13. PMID 17682050, Free PMC Article
    3. Functional genomic analysis of the Drosophila immune response. Valanne S. Dev Comp Immunol, 2014 Jan. PMID 23707784
    4. Stem cell mTOR signaling directs region-specific cell fate decisions during intestinal nutrient adaptation. Mattila J, et al. Sci Adv, 2024 Feb 9. PMID 38335286, Free PMC Article
    5. Analysis of Drosophila segmentation network identifies a JNK pathway factor overexpressed in kidney cancer. Liu J, et al. Science, 2009 Feb 27. PMID 19164706, Free PMC Article

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in intracellular transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of canonical Wnt signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in nuclear export IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein export from nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein export from nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Ran binding protein 3
    Names
    CG10225-PA
    CG10225-PB
    RanBP3-PA
    RanBP3-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      23750937..23752834 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001275952.1 → NP_001262881.1  Ran binding protein 3, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262881.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KGQ0
      Conserved Domains (1) summary
      cd13180
      Location:242 → 351
      RanBD_RanBP3; Ran-binding protein 3 Ran-binding domain

    2. NM_142921.4 → NP_651178.1  Ran binding protein 3, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651178.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VCI7
      Related
      FBpp0083859
      Conserved Domains (1) summary
      cd13180
      Location:243 → 352
      RanBD_RanBP3; Ran-binding protein 3 Ran-binding domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KGQ0 A0A0B4KGQ0
    Q9VCI7 Q9VCI7

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