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    CG5973 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34023, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG5973provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0031914
    Locus tag
    Dmel_CG5973
    See related
    AllianceGenome:FB:FBgn0031914
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG5973
    Summary
    Predicted to enable phosphatidylinositol bisphosphate binding activity. Is expressed in adult head; amnioserosa; embryonic/larval midgut; and yolk nucleus. Orthologous to human TTPAL (alpha tocopherol transfer protein like). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG5973 in Genome Data Viewer
    Location:
    27F4-28A1; 2-26 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (7437492..7445882)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (7437492..7445882)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene midline uncoordinated Neighboring gene uncharacterized protein Neighboring gene scavenger receptor acting in neural tissue and majority of rhodopsin is absent Neighboring gene Gustatory receptor 28a Neighboring gene Gustatory receptor 28b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Dissection of the pathway required for generation of vitamin A and for Drosophila phototransduction. Wang T, et al. J Cell Biol, 2007 Apr 23. PMID 17452532, Free PMC Article
    2. Microarray analysis of the gene expression profiles of SL2 cells stimulated by LPS/PGN and curdlan. Jin LH, et al. Mol Cells, 2008 Jun 30. PMID 18460901
    3. Identification of receptor-tyrosine-kinase-signaling target genes reveals receptor-specific activities and pathway branchpoints during Drosophila development. Leatherbarrow JR, et al. Genetics, 2009 Apr. PMID 19189950, Free PMC Article
    4. Post-transcriptional repression of the Drosophila midkine and pleiotrophin homolog miple by HOW is essential for correct mesoderm spreading. Toledano-Katchalski H, et al. Development, 2007 Oct. PMID 17728343
    5. Drosophila ribosomal proteins are associated with linker histone H1 and suppress gene transcription. Ni JQ, et al. Genes Dev, 2006 Jul 15. PMID 16816001, Free PMC Article

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables phosphatidylinositol bisphosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG5973-PA
    CG5973-PB
    CG5973-PC
    CG5973-PD
    CG5973-PE
    CG5973-PF
    CG5973-PG

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      7437492..7445882
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001273268.2 → NP_001260197.1  uncharacterized protein Dmel_CG5973, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260197.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VM11
      Conserved Domains (2) summary
      smart01100
      Location:51 → 96
      CRAL_TRIO_N; CRAL/TRIO, N-terminal domain
      cd00170
      Location:116 → 272
      SEC14; Sec14p-like lipid-binding domain. Found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to ...

    2. NM_164750.2 → NP_723275.1  uncharacterized protein Dmel_CG5973, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723275.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VM11
      Related
      FBpp0079074
      Conserved Domains (2) summary
      smart01100
      Location:51 → 96
      CRAL_TRIO_N; CRAL/TRIO, N-terminal domain
      cd00170
      Location:116 → 272
      SEC14; Sec14p-like lipid-binding domain. Found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to ...

    3. NM_001169430.3 → NP_001162901.1  uncharacterized protein Dmel_CG5973, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001162901.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VM11
      Conserved Domains (2) summary
      smart01100
      Location:51 → 96
      CRAL_TRIO_N; CRAL/TRIO, N-terminal domain
      cd00170
      Location:116 → 272
      SEC14; Sec14p-like lipid-binding domain. Found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to ...

    4. NM_001273269.1 → NP_001260198.1  uncharacterized protein Dmel_CG5973, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260198.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VM11
      Conserved Domains (2) summary
      smart01100
      Location:51 → 96
      CRAL_TRIO_N; CRAL/TRIO, N-terminal domain
      cd00170
      Location:116 → 272
      SEC14; Sec14p-like lipid-binding domain. Found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to ...

    5. NM_164751.2 → NP_723276.1  uncharacterized protein Dmel_CG5973, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723276.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VM11
      Related
      FBpp0079075
      Conserved Domains (2) summary
      smart01100
      Location:51 → 96
      CRAL_TRIO_N; CRAL/TRIO, N-terminal domain
      cd00170
      Location:116 → 272
      SEC14; Sec14p-like lipid-binding domain. Found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to ...

    6. NM_135276.3 → NP_609120.1  uncharacterized protein Dmel_CG5973, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609120.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VM11
      Related
      FBpp0079076
      Conserved Domains (2) summary
      smart01100
      Location:51 → 96
      CRAL_TRIO_N; CRAL/TRIO, N-terminal domain
      cd00170
      Location:116 → 272
      SEC14; Sec14p-like lipid-binding domain. Found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to ...

    7. NM_001298781.1 → NP_001285710.1  uncharacterized protein Dmel_CG5973, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285710.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VM11
      Conserved Domains (2) summary
      smart01100
      Location:51 → 96
      CRAL_TRIO_N; CRAL/TRIO, N-terminal domain
      cd00170
      Location:116 → 272
      SEC14; Sec14p-like lipid-binding domain. Found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VM11 Q9VM11

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