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    Balat Beta-alanine transporter [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36417, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Balatprovided by FlyBase
    Official Full Name
    Beta-alanine transporterprovided by FlyBase
    Primary source
    FLYBASE:FBgn0033778
    Locus tag
    Dmel_CG3790
    See related
    AllianceGenome:FB:FBgn0033778
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    balat; BalaT; CG3790; CT; Dmel\CG3790
    Summary
    Enables beta-alanine transmembrane transporter activity. Involved in beta-alanine transport and histamine biosynthetic process. Located in plasma membrane. Is expressed in adult head; eye; pigment cell; and spermatozoon. Human ortholog(s) of this gene implicated in acute kidney failure. Orthologous to human SLC22A1 (solute carrier family 22 member 1); SLC22A2 (solute carrier family 22 member 2); and SLC22A3 (solute carrier family 22 member 3). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See Balat in Genome Data Viewer
    Location:
    49D6-49D6; 2-67 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (12872787..12875012, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (8760292..8762517, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR45140 Neighboring gene antisense RNA:CR43469 Neighboring gene bicaudal Neighboring gene antisense RNA:CR43468 Neighboring gene Lifeguard Neighboring gene Aspartyl-tRNA synthetase Neighboring gene N-methyl-D-aspartate receptor-associated protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Insights into the mechanism of histamine synthesis and recycling disruption induced by exposure to CdO NPs in the fruit fly (Drosophila melanogaster). El Kholy S, et al. Environ Sci Pollut Res Int, 2023 Jul. PMID 37340164
    2. Exposure to a sublethal concentration of CdO nanoparticles impairs the vision of the fruit fly (Drosophila melanogaster) by disrupting histamine synthesis and recycling mechanisms. El Kholy S, et al. Environ Sci Pollut Res Int, 2023 Feb. PMID 36394804
    3. Histamine Recycling Is Mediated by CarT, a Carcinine Transporter in Drosophila Photoreceptors. Xu Y, et al. PLoS Genet, 2015 Dec. PMID 26713872, Free PMC Article
    4. Novel slc22 transporter homologs in fly, worm, and human clarify the phylogeny of organic anion and cation transporters. Eraly SA, et al. Physiol Genomics, 2004 Jun 17. PMID 15054140
    5. A Closer Look at Histamine in Drosophila. Volonté C, et al. Int J Mol Sci, 2024 Apr 18. PMID 38674034, Free PMC Article

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables beta-alanine transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in beta-alanine transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in histamine biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Beta-alanine transporter
    Names
    Balat-PA
    CG3790-PA
    carnitine transporter

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      12872787..12875012 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136979.3 → NP_610823.1  Beta-alanine transporter [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610823.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q961J5, Q9V6H5
      Related
      FBpp0086928
      Conserved Domains (1) summary
      cd17317
      Location:128 → 524
      MFS_SLC22; Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q961J5.1 Q961J5

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