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    Fmo-2 Flavin-containing monooxygenase 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35561, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Fmo-2provided by FlyBase
    Official Full Name
    Flavin-containing monooxygenase 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0033079
    Locus tag
    Dmel_CG3174
    See related
    AllianceGenome:FB:FBgn0033079
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG3174; Dmel\CG3174; DmFMO-2; Dmfmo2; fmo2
    Summary
    Enables monooxygenase activity. Located in cytosol and mitochondrion. Is expressed in several structures, including adult head; corpus cardiacum primordium; embryonic stomatogastric nervous system; embryonic/larval midgut primordium; and neurohemal organ. Used to study chromosome 1q21.1 deletion syndrome. Human ortholog(s) of this gene implicated in hypertension; inherited metabolic disorder; and trimethylaminuria. Orthologous to several human genes including FMO1 (flavin containing dimethylaniline monoxygenase 1); FMO3 (flavin containing dimethylaniline monoxygenase 3); and FMO5 (flavin containing dimethylaniline monoxygenase 5). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Fmo-2 in Genome Data Viewer
    Location:
    42B2-42B2; 2-55 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (6642418..6645098, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (2529923..2532603, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Trap1 Neighboring gene Brahma associated protein 170kD Neighboring gene Death executioner Bcl-2 Neighboring gene Optix-binding protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Constraints on the evolution of a doublesex target gene arising from doublesex's pleiotropic deployment. Luo SD, et al. Proc Natl Acad Sci U S A, 2015 Feb 24. PMID 25675536, Free PMC Article
    2. Catalytic activity and expression of two flavin-containing monooxygenases from Drosophila melanogaster. Scharf ME, et al. Arch Insect Biochem Physiol, 2004 Sep. PMID 15352153
    3. Effects of methimazole on Drosophila glucolipid metabolism in vitro and in vivo. Wei Q, et al. Comp Biochem Physiol C Toxicol Pharmacol, 2017 Jun. PMID 28341216
    4. Drosophila Bcl-2 proteins participate in stress-induced apoptosis, but are not required for normal development. Sevrioukov EA, et al. Genesis, 2007 Apr. PMID 17417787
    5. Sex Differences in Drosophila Somatic Gene Expression: Variation and Regulation by doublesex. Arbeitman MN, et al. G3 (Bethesda), 2016 Jul 7. PMID 27172187, Free PMC Article

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The Flavin-containing monooxygenase-2 (Fmo-2) gene, a likely direct dsx target, was investigated to elucidate how sexually dimorphic expression and its evolution are brought about.
      Title: Constraints on the evolution of a doublesex target gene arising from doublesex's pleiotropic deployment.
    2. DmFMO-2 may have a general housekeeping function.
      Title: Catalytic activity and expression of two flavin-containing monooxygenases from Drosophila melanogaster.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables N,N-dimethylaniline monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables NADP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables flavin adenine dinucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monooxygenase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Flavin-containing monooxygenase 2
    Names
    CG3174-PA
    Fmo-2-PA
    NP_610217.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      6642418..6645098 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136373.4 → NP_610217.1  Flavin-containing monooxygenase 2 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610217.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K3U4, Q95V23
      Related
      FBpp0085481
      Conserved Domains (1) summary
      cl21454
      Location:12 → 214
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7K3U4 Q7K3U4
    Q95V23 Q95V23

    Gene LinkOut

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