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    eIF4E3 eukaryotic translation initiation factor 4E3 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38923, updated on 9-Dec-2024

    Summary

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    Official Symbol
    eIF4E3provided by FlyBase
    Official Full Name
    eukaryotic translation initiation factor 4E3provided by FlyBase
    Primary source
    FLYBASE:FBgn0265089
    Locus tag
    Dmel_CG8023
    See related
    AllianceGenome:FB:FBgn0265089
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0140519.227; CG8023; Dmel\CG8023; eIF43; eIF4E; eIF4E-3; eIF4F; elF4E-3; l(3)0139; l(3)L0139
    Summary
    Enables RNA 7-methylguanosine cap binding activity and eukaryotic initiation factor 4G binding activity. Involved in positive regulation of translation and spermatogenesis. Located in cytoplasm. Part of eukaryotic translation initiation factor 4F complex. Is expressed in several structures, including male germline cell and testis. Human ortholog(s) of this gene implicated in autistic disorder. Orthologous to human EIF4E (eukaryotic translation initiation factor 4E) and EIF4E1B (eukaryotic translation initiation factor 4E family member 1B). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See eIF4E3 in Genome Data Viewer
    Location:
    66C1-66C1; 3-24 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (8229224..8230568)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (8222324..8223668)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR43953 Neighboring gene uncharacterized protein Neighboring gene Down syndrome cell adhesion molecule 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila Me31B is a Dual eIF4E-Interacting Protein. Layana C, et al. J Mol Biol, 2023 Mar 1. PMID 36638908
    2. Loss-of-function analysis reveals distinct requirements of the translation initiation factors eIF4E, eIF4E-3, eIF4G and eIF4G2 in Drosophila spermatogenesis. Ghosh S, et al. PLoS One, 2015. PMID 25849588, Free PMC Article
    3. An autoregulatory switch in sex-specific phf7 transcription causes loss of sexual identity and tumors in the Drosophila female germline. Smolko AE, et al. Development, 2020 Sep 11. PMID 32816970, Free PMC Article
    4. eIF4E as a molecular wildcard in metazoans RNA metabolism. Hernández G, et al. Biol Rev Camb Philos Soc, 2023 Dec. PMID 37553111
    5. Diverse cap-binding properties of Drosophila eIF4E isoforms. Zuberek J, et al. Biochim Biophys Acta, 2016 Oct. PMID 27374989

    See all (58) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA 7-methylguanosine cap binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA 7-methylguanosine cap binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA cap binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables eukaryotic initiation factor 4G binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables translation initiation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to translation initiation factor activity IC
    Inferred by Curator
    more info
    		 PubMed 
    enables translation initiation factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables translation initiation factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables translation initiation factor binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of translation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in translational initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in translational initiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of eukaryotic translation initiation factor 4F complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of eukaryotic translation initiation factor 4F complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of eukaryotic translation initiation factor 4F complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    eukaryotic translation initiation factor 4E3
    Names
    CG8023-PA
    eIF4E-3
    eIF4E3-PA
    eukaryotic translation initiation factor 4E-3
    lethal (3) L0139

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      8229224..8230568
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_139937.2 → NP_648194.1  eukaryotic translation initiation factor 4E3 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648194.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VSG1
      Related
      FBpp0076424
      Conserved Domains (1) summary
      pfam01652
      Location:71 → 224
      IF4E; Eukaryotic initiation factor 4E
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VSG1 Q9VSG1

    Gene LinkOut

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