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    CG8611 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32725, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG8611provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0027602
    Locus tag
    Dmel_CG8611
    See related
    AllianceGenome:FB:FBgn0027602
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:GH02833; cg8611; Dmel\CG8611; DmRH11
    Summary
    Predicted to enable RNA helicase activity. Predicted to be involved in ribosome biogenesis. Predicted to be active in nucleus. Is expressed in several structures, including embryonic/larval midgut; embryonic/larval midgut primordium; larval muscle cell; mesoderm; and spermatozoon. Orthologous to human DDX31 (DEAD-box helicase 31). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG8611 in Genome Data Viewer
    Location:
    16A5-16A5; 1-57 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (17413267..17422145, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (17307300..17316178, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR43491 Neighboring gene BarH1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Endo-beta-N-acetylglucosaminidase Neighboring gene presidents-cup

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Rare recombination events generate sequence diversity among balancer chromosomes in Drosophila melanogaster. Miller DE, et al. Proc Natl Acad Sci U S A, 2016 Mar 8. PMID 26903656, Free PMC Article
    2. DDX56 Binds to Chikungunya Virus RNA To Control Infection. Taschuk F, et al. mBio, 2020 Oct 27. PMID 33109765, Free PMC Article
    3. Stem-loop recognition by DDX17 facilitates miRNA processing and antiviral defense. Moy RH, et al. Cell, 2014 Aug 14. PMID 25126784, Free PMC Article
    4. Evolution of intron/exon structure of DEAD helicase family genes in Arabidopsis, Caenorhabditis, and Drosophila. Boudet N, et al. Genome Res, 2001 Dec. PMID 11731501, Free PMC Article
    5. RNA silencing in the antiviral innate immune defence--role of DEAD-box RNA helicases. Ulvila J, et al. Scand J Immunol, 2010 Mar. PMID 20415780

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA helicase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in ribosome biogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG8611-PA
    CG8611-PB
    CG8611-PC
    NP_001285372.1
    NP_573214.1
    NP_788922.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      17413267..17422145 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_176749.2 → NP_788922.1  uncharacterized protein Dmel_CG8611, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788922.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q86B47, Q9VX53, Q9Y159
      UniProtKB/TrEMBL
      E8NHB2
      Related
      FBpp0074214
      Conserved Domains (5) summary
      smart00487
      Location:348 → 554
      DEXDc; DEAD-like helicases superfamily
      cd00079
      Location:601 → 757
      HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
      pfam10310
      Location:203 → 285
      DUF2413; Protein of unknown function (DUF2413)
      pfam13959
      Location:805 → 866
      DUF4217; Domain of unknown function (DUF4217)
      cl21455
      Location:332 → 548
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    2. NM_132986.5 → NP_573214.1  uncharacterized protein Dmel_CG8611, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_573214.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E8NHB2
      Related
      FBpp0074213
      Conserved Domains (5) summary
      smart00487
      Location:347 → 553
      DEXDc; DEAD-like helicases superfamily
      cd00079
      Location:600 → 756
      HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
      pfam10310
      Location:202 → 284
      DUF2413; Protein of unknown function (DUF2413)
      pfam13959
      Location:804 → 865
      DUF4217; Domain of unknown function (DUF4217)
      cl21455
      Location:331 → 547
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    3. NM_001298443.1 → NP_001285372.1  uncharacterized protein Dmel_CG8611, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285372.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E8NHB2, X2JKW3
      Conserved Domains (4) summary
      smart00487
      Location:348 → 554
      DEXDc; DEAD-like helicases superfamily
      cd00079
      Location:601 → 757
      HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
      pfam10310
      Location:203 → 285
      DUF2413; Protein of unknown function (DUF2413)
      cl21455
      Location:332 → 548
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q86B47.1 Q86B47
    X2JKW3 X2JKW3

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