Debcl Death executioner Bcl-2 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Debclprovided by FlyBase
Official Full Name: Death executioner Bcl-2provided by FlyBase
Primary source: FLYBASE:FBgn0029131
Locus tag: Dmel_CG33134
See related: AllianceGenome:FB:FBgn0029131
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: Bak/Bax; Bcl 2; bcl-2; Bcl-2; Bcl2; BG1; Bok; BOK; Bok(Debcl); borg1/debcl; buffy; CG12397; CG33134; dbok; dBok; dBOK; Dbok; DBok; dbok/debcl; dBorg-1; dBORG-1/DROB-1/DEBCL/dBOK; dBorg01; dborg1; dBorg1; dBrog-1; debc1; debcl; DEBCL; debcl/Borg1; Debcl/dBorg-1/dBok/Drob-1; Debcl/dBorg-1/dRob-1; Debcl/Drob-1/dBorg-1/dBok; debok; Dmel\CG33134; drob-1; Drob-1; Drob-1/Debcl/dBORG-1; Drob-1/Debcl/dBorg-1/dBok; Drob-1/Debcl/dBorg-1/DBok
Summary: Predicted to enable channel activity. Involved in several processes, including ectopic germ cell programmed cell death; intrinsic apoptotic signaling pathway in response to DNA damage; and positive regulation of programmed necrotic cell death. Located in mitochondrial envelope. Part of Bcl-2 family protein complex. Is expressed in several structures, including anterior-posterior subdivision of organism; embryonic/larval gut; female germline cell; gut section; and imaginal disc. Orthologous to human BOK (BCL2 family apoptosis regulator BOK). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 42B2-42C1; 2-55 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (6648654..6652842)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (2536159..2540347)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Bcl-2 Orthologues, Buffy and Debcl, Can Suppress Drp1-Dependent Age-Related Phenotypes in Drosophila.
Title: Bcl-2 Orthologues, Buffy and Debcl, Can Suppress Drp1-Dependent Age-Related Phenotypes in Drosophila.
Debcl modulates Drp1 mitochondrial localization during apoptosis.
Title: The Drosophila retinoblastoma protein, Rbf1, induces a Debcl- and Drp1-dependent mitochondrial apoptosis.
Slimb targets Bax and Debcl to the proteasome.
Title: The drosophila Bcl-2 family protein Debcl is targeted to the proteasome by the β-TrCP homologue slimb.
dNF-Y regulates debcl gene expression.
Title: dNF-YB plays dual roles in cell death and cell differentiation during Drosophila eye development.
Although gross development and lifespans were unaffected, we found that Debcl was required for pruning cells in the developing central nervous system.
Title: The Bax/Bak ortholog in Drosophila, Debcl, exerts limited control over programmed cell death.
Developmental programmed cell death regulation in the fly does not rely upon the Bcl-2 proteins.
Title: Drosophila Bcl-2 proteins participate in stress-induced apoptosis, but are not required for normal development.
Drob-1 functions as an antiapoptotic protein in neuronal cells by regulating mitochondrial homeostasis.
Title: Bax-like protein Drob-1 protects neurons from expanded polyglutamine-induced toxicity in Drosophila.
BUFFY and DEBCL localize to distinct intracellular membranes, DEBCL predominantly to mitochondria and BUFFY to endoplasmic reticula
Title: Molecular determinants of the subcellular localization of the Drosophila Bcl-2 homologues DEBCL and BUFFY.
Buffy is a protein homolog of debcl.
Title: Buffy, a Drosophila Bcl-2 protein, has anti-apoptotic and cell cycle inhibitory functions.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables channel activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in apoptotic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in apoptotic process	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in apoptotic process involved in morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
NOT involved_in autophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to starvation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ectopic germ cell programmed cell death	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in extrinsic apoptotic signaling pathway in absence of ligand	IBA Inferred from Biological aspect of Ancestor more info
involved_in intrinsic apoptotic signaling pathway in response to DNA damage	IBA Inferred from Biological aspect of Ancestor more info
involved_in intrinsic apoptotic signaling pathway in response to DNA damage	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of neuron apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron cellular homeostasis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of macroautophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of programmed necrotic cell death	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in programmed cell death involved in cell development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in regulation of programmed cell death	IGI Inferred from Genetic Interaction more info	PubMed
involved_in release of cytochrome c from mitochondria	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to ionizing radiation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of Bcl-2 family protein complex	IPI Inferred from Physical Interaction more info	PubMed
located_in mitochondrial envelope	IDA Inferred from Direct Assay more info	PubMed
is_active_in mitochondrial outer membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: death executioner Bcl-2

Names: Bcl-2; CG33134-PA; Debcl-PA; death executioner Bcl-2 homologue; death inducing Bcl-2-like protein; deborg

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033778.4 Reference assembly

Range

6648654..6652842

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_176098.3 → NP_788278.1 death executioner Bcl-2 [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_788278.1

Status: REVIEWED

UniProtKB/TrEMBL

Q7KM33, Q9V9C8

Related

FBpp0085443

Conserved Domains (1) summary

cd06845
Location:107 → 257

Bcl-2_like; Apoptosis regulator proteins of the Bcl-2 family, named after B-cell lymphoma 2. This alignment model spans what have been described as Bcl-2 homology regions BH1, BH2, BH3, and BH4. Many members of this family have an additional C-terminal transmembrane ...