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    CG9399 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41157, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG9399provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0037715
    Locus tag
    Dmel_CG9399
    See related
    AllianceGenome:FB:FBgn0037715
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG9399; dMPC2
    Summary
    Predicted to enable pyruvate transmembrane transporter activity. Predicted to be involved in mitochondrial pyruvate transmembrane transport. Predicted to be located in membrane. Predicted to be active in mitochondrial inner membrane. Is expressed in adult head; adult heart; and organism. Used to study intestinal cancer. Orthologous to human MPC2 (mitochondrial pyruvate carrier 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG9399 in Genome Data Viewer
    Location:
    85D25-85D25; 3-48 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (9571911..9574211, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (5397633..5399933, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene karyopherin alpha3 Neighboring gene Son RNA binding protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Control of intestinal stem cell function and proliferation by mitochondrial pyruvate metabolism. Schell JC, et al. Nat Cell Biol, 2017 Sep. PMID 28812582, Free PMC Article
    2. Aralar Sequesters GABA into Hyperactive Mitochondria, Causing Social Behavior Deficits. Kanellopoulos AK, et al. Cell, 2020 Mar 19. PMID 32200800
    3. Glial Metabolic Rewiring Promotes Axon Regeneration and Functional Recovery in the Central Nervous System. Li F, et al. Cell Metab, 2020 Nov 3. PMID 32941799, Free PMC Article
    4. Identification of a mitochondrial target of thiazolidinedione insulin sensitizers (mTOT)--relationship to newly identified mitochondrial pyruvate carrier proteins. Colca JR, et al. PLoS One, 2013. PMID 23690925, Free PMC Article
    5. The Identification and Evolutionary Trends of the Solute Carrier Superfamily in Arthropods. Denecke SM, et al. Genome Biol Evol, 2020 Aug 1. PMID 32681801, Free PMC Article

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables pyruvate transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables pyruvate transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitochondrial pyruvate transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial pyruvate transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrial pyruvate transmembrane transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane ISM
    Inferred from Sequence Model
    more info
    		  
    is_active_in mitochondrial inner membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial inner membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG9399-PA
    CG9399-PB
    CG9399-PD
    CG9399-PE

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      9571911..9574211 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001275496.1 → NP_001262425.1  uncharacterized protein Dmel_CG9399, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262425.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KFZ7
      Conserved Domains (1) summary
      pfam03650
      Location:12 → 105
      MPC; uncharacterized protein family (UPF0041)

    2. NM_141656.2 → NP_649913.1  uncharacterized protein Dmel_CG9399, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649913.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VHB1
      Related
      FBpp0081588
      Conserved Domains (1) summary
      pfam03650
      Location:46 → 139
      MPC; uncharacterized protein family (UPF0041)

    3. NM_169294.2 → NP_731376.1  uncharacterized protein Dmel_CG9399, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_731376.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VHB1
      Related
      FBpp0081587
      Conserved Domains (1) summary
      pfam03650
      Location:46 → 139
      MPC; uncharacterized protein family (UPF0041)

    4. NM_001170100.2 → NP_001163571.1  uncharacterized protein Dmel_CG9399, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163571.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VHB1
      Conserved Domains (1) summary
      pfam03650
      Location:46 → 139
      MPC; uncharacterized protein family (UPF0041)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KFZ7 A0A0B4KFZ7
    Q9VHB1 Q9VHB1

    Gene LinkOut

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