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    RabGGTa Rab geranylgeranyltransferase subunit alpha [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40617, updated on 9-Dec-2024

    Summary

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    Official Symbol
    RabGGTaprovided by FlyBase
    Official Full Name
    Rab geranylgeranyltransferase subunit alphaprovided by FlyBase
    Primary source
    FLYBASE:FBgn0037293
    Locus tag
    Dmel_CG12007
    See related
    AllianceGenome:FB:FBgn0037293
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG12007; Dmel\CG12007; PTAR3; RabGGTalpha
    Summary
    Contributes to Rab geranylgeranyltransferase activity. Predicted to be involved in endoplasmic reticulum to Golgi vesicle-mediated transport. Part of Rab-protein geranylgeranyltransferase complex. Is expressed in organism. Orthologous to human RABGGTA (Rab geranylgeranyltransferase subunit alpha). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See RabGGTa in Genome Data Viewer
    Location:
    82F1-82F1; 3-47.5 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (5128087..5129939)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (953809..955661)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene corto Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene defective proboscis extension response 16 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Regulation of Drosophila eye development by the transcription factor Sine oculis. Jusiak B, et al. PLoS One, 2014. PMID 24586968, Free PMC Article
    2. Isoprenoids control germ cell migration downstream of HMGCoA reductase. Santos AC, et al. Dev Cell, 2004 Feb. PMID 14960281
    3. Drosophila Tempura, a novel protein prenyltransferase α subunit, regulates notch signaling via Rab1 and Rab11. Charng WL, et al. PLoS Biol, 2014 Jan. PMID 24492843, Free PMC Article
    4. Genome-wide mapping of in vivo targets of the Drosophila transcription factor Kruppel. Matyash A, et al. J Biol Chem, 2004 Jul 16. PMID 15131112
    5. Identification and functional analysis of healing regulators in Drosophila. Álvarez-Fernández C, et al. PLoS Genet, 2015. PMID 25647511, Free PMC Article

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    contributes_to Rab geranylgeranyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to Rab geranylgeranyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein prenyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein prenylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of Rab-protein geranylgeranyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Rab-protein geranylgeranyltransferase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Rab geranylgeranyltransferase subunit alpha
    Names
    CG12007-PA
    RabGGTa-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      5128087..5129939
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_141255.3 → NP_649512.1  Rab geranylgeranyltransferase subunit alpha [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649512.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VN77
      Related
      FBpp0078483
      Conserved Domains (2) summary
      COG5536
      Location:21 → 267
      BET4; Protein prenyltransferase, alpha subunit [Posttranslational modification, protein turnover, chaperones]
      pfam01239
      Location:124 → 151
      PPTA; Protein prenyltransferase alpha subunit repeat
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VN77 Q9VN77

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