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    epsilonCOP Coat Protein (coatomer) epsilon [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33908, updated on 9-Dec-2024

    Summary

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    Official Symbol
    epsilonCOPprovided by FlyBase
    Official Full Name
    Coat Protein (coatomer) epsilonprovided by FlyBase
    Primary source
    FLYBASE:FBgn0027496
    Locus tag
    Dmel_CG9543
    See related
    AllianceGenome:FB:FBgn0027496
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    bcDNA:LD29885; BcDNA:LD29885; CG9543; Dmel\CG9543; epsilon-Cop; epsilon-COP
    Summary
    Predicted to enable structural molecule activity. Predicted to be involved in endoplasmic reticulum to Golgi vesicle-mediated transport and intra-Golgi vesicle-mediated transport. Part of COPI vesicle coat. Is expressed in adult head; embryonic/larval salivary gland; embryonic/larval salivary gland body; organism; and salivary gland body primordium. Orthologous to human COPE (COPI coat complex subunit epsilon). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See epsilonCOP in Genome Data Viewer
    Location:
    26D9-26D9; 2-20 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (6489090..6490194)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (6489090..6490194)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45463 Neighboring gene Daxx-like protein Neighboring gene Kynurenine formamidase Neighboring gene PHD finger protein 5a Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. COPI activity coupled with fatty acid biosynthesis is required for viral replication. Cherry S, et al. PLoS Pathog, 2006 Oct. PMID 17040126, Free PMC Article
    2. Golgi-dependent reactivation and regeneration of Drosophila quiescent neural stem cells. Gujar MR, et al. Dev Cell, 2023 Oct 9. PMID 37567172
    3. Expression of COPI components during development of Drosophila melanogaster. Grieder NC, et al. Gene Expr Patterns, 2005 Dec. PMID 16169286
    4. COPI complex is a regulator of lipid homeostasis. Beller M, et al. PLoS Biol, 2008 Nov 25. PMID 19067489, Free PMC Article
    5. Functional genomic screen reveals genes involved in lipid-droplet formation and utilization. Guo Y, et al. Nature, 2008 May 29. PMID 18408709, Free PMC Article

    See all (45) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables structural molecule activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intra-Golgi vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of COPI vesicle coat IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of COPI vesicle coat IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    coat protein (coatomer) epsilon
    Names
    CG9543-PA
    COPI epsilon subunit
    epsilonCOP-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      6489090..6490194
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_135193.3 → NP_609037.1  coat protein (coatomer) epsilon [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609037.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9Y0Y5
      Related
      FBpp0078891
      Conserved Domains (2) summary
      pfam04733
      Location:12 → 296
      Coatomer_E; Coatomer epsilon subunit
      sd00006
      Location:175 → 201
      TPR; TPR repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Y0Y5 Q9Y0Y5

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