e(y)3 enhancer of yellow 3 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: e(y)3provided by FlyBase
Official Full Name: enhancer of yellow 3provided by FlyBase
Primary source: FLYBASE:FBgn0087008
Locus tag: Dmel_CG12238
See related: AllianceGenome:FB:FBgn0087008
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG12238; Dmel\CG12238; E(y)3; e(y)[3]; l(1)G0084; l(1)G0266; l(1)G0283; l(1)G0381; l(1)G0409; sayp; SAYP
Summary: Enables chromatin binding activity; transcription coactivator activity; and transcription corepressor activity. Involved in chromatin remodeling; negative regulation of DNA-templated transcription; and positive regulation of DNA-templated transcription. Located in chromosome and nucleus. Part of brahma complex. Is expressed in several structures, including anterior endoderm anlage; central brain primordium; embryonic/larval midgut primordium; ganglia; and mesoderm. Used to study Coffin-Siris syndrome. Orthologous to human PHF10 (PHD finger protein 10). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 18D8-18D11; 1-63 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (19626548..19638369, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (19520581..19532402, complement)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Subunits of the PBAP Chromatin Remodeler Are Capable of Mediating Enhancer-Driven Transcription in Drosophila.
Title: Subunits of the PBAP Chromatin Remodeler Are Capable of Mediating Enhancer-Driven Transcription in Drosophila.
In the repressed state of the ftz-f1 gene, the Pol II complex is pre-recruited on the promoter; Pol II starts transcription but is paused 1.5 kb downstream of the promoter, with SAYP and Brahma forming a nucleosomal barrier ahead of paused Pol II.
Title: SAYP and Brahma are important for 'repressive' and 'transient' Pol II pausing.
SAYP interacts with DHR3 nuclear receptor and activates the corresponding genes by recruiting the BTFly (Brahma and TFIID) coactivator supercomplex during development and have multiple common targets across the genome.
Title: [SAYP interacts with DHR3 nuclear receptor and participates in ecdysone-dependent transcription regulation].
The transcription coactivators SAYP and ENY2 act in gene expression as cooperative nanoregulators,determining the molecular mechanisms of spatial and temporal coordination of the processes involved in the realization of genetic information.
Title: [Functioning of macromolecular complexes at successive stages of gene expression as self-coordinated molecular machines].
DHR3 and SAYP interact during development and have multiple common targets across the genome
Title: SAYP interacts with DHR3 nuclear receptor and participates in ecdysone-dependent transcription regulation.
Novel conservative domain of SAYP coactivator mediates TFIID and Brahma transcriptional complexes interaction
Title: [Novel conservative domain of SAYP coactivator mediates TFIID and Brahma transcriptional complexes interaction].
SAYP serves as a basis for assembling the BTFly nuclear supercomplex consising of the Brahma and TFIID coactivators. BTFly may play an important role in ontogenesis.
Title: [SAYP--a novel regulator of metazoan development].
The existence of a stable coactivator supercomplex consisting of the chromatin-remodeling factor Brahma (SWI/SNF) and the transcription initiation factor TFIID, is shown.
Title: Transcription coactivator SAYP combines chromatin remodeler Brahma and transcription initiation factor TFIID into a single supercomplex.
SAYP is a signature subunit that plays a major role in the functional specificity of the PBAP holoenzyme.
Title: The transcriptional coactivator SAYP is a trithorax group signature subunit of the PBAP chromatin remodeling complex.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables transcription coactivator activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables transcription corepressor activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in chromatin remodeling	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of brahma complex	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in euchromatin	IDA Inferred from Direct Assay more info	PubMed
located_in heterochromatin	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in polytene chromosome	IDA Inferred from Direct Assay more info	PubMed
located_in polytene chromosome chromocenter	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: enhancer of yellow 3

Names: CG12238-PA; CG12238-PB; CG12238-PC; CG12238-PD; CG12238-PE; SAYP; e(y)3-PA; e(y)3-PB; e(y)3-PC; e(y)3-PD; e(y)3-PE; lethal (1) G0084; supporter of activation of yellow protein

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004354.4 Reference assembly

Range

19626548..19638369 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001272789.1 → NP_001259718.1 enhancer of yellow 3, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001259718.1

Status: REVIEWED

UniProtKB/Swiss-Prot

C7LAD9, Q7JW70, Q9VWF2

UniProtKB/TrEMBL

M9PHL0

Conserved Domains (3) summary

sd00025
Location:1694 → 1719

zf-RanBP2; RanBP2-type Zn finger [structural motif]

cd15529
Location:1750 → 1793

PHD2_PHF10; PHD finger 2 found in PHD finger protein 10 (PHF10) and similar proteins

cl22851
Location:1694 → 1748

PHD_SF; PHD finger superfamily
NM_001272792.1 → NP_001259721.1 enhancer of yellow 3, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001259721.1

Status: REVIEWED

UniProtKB/Swiss-Prot

C7LAD9, Q7JW70, Q9VWF2

UniProtKB/TrEMBL

M9PHL0

Conserved Domains (3) summary

sd00025
Location:1694 → 1719

zf-RanBP2; RanBP2-type Zn finger [structural motif]

cd15529
Location:1750 → 1793

PHD2_PHF10; PHD finger 2 found in PHD finger protein 10 (PHF10) and similar proteins

cl22851
Location:1694 → 1748

PHD_SF; PHD finger superfamily
NM_134490.3 → NP_608334.3 enhancer of yellow 3, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_608334.3

Status: REVIEWED

UniProtKB/Swiss-Prot

C7LAD9, Q7JW70, Q9VWF2

UniProtKB/TrEMBL

M9PHL0

Related

FBpp0074531

Conserved Domains (3) summary

sd00025
Location:1694 → 1719

zf-RanBP2; RanBP2-type Zn finger [structural motif]

cd15529
Location:1750 → 1793

PHD2_PHF10; PHD finger 2 found in PHD finger protein 10 (PHF10) and similar proteins

cl22851
Location:1694 → 1748

PHD_SF; PHD finger superfamily
NM_001272790.1 → NP_001259719.1 enhancer of yellow 3, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001259719.1

Status: REVIEWED

UniProtKB/TrEMBL

M9PI16

Conserved Domains (3) summary

sd00025
Location:1700 → 1725

zf-RanBP2; RanBP2-type Zn finger [structural motif]

cd15529
Location:1756 → 1799

PHD2_PHF10; PHD finger 2 found in PHD finger protein 10 (PHF10) and similar proteins

cl22851
Location:1700 → 1754

PHD_SF; PHD finger superfamily
NM_001272791.1 → NP_001259720.1 enhancer of yellow 3, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001259720.1

Status: REVIEWED

UniProtKB/TrEMBL

M9PHZ0

Conserved Domains (3) summary

sd00025
Location:1699 → 1724

zf-RanBP2; RanBP2-type Zn finger [structural motif]

cd15529
Location:1755 → 1798

PHD2_PHF10; PHD finger 2 found in PHD finger protein 10 (PHF10) and similar proteins

cl22851
Location:1699 → 1753

PHD_SF; PHD finger superfamily