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    DIP2 DISCO Interacting Protein 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 252479, updated on 9-Dec-2024

    Summary

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    Official Symbol
    DIP2provided by FlyBase
    Official Full Name
    DISCO Interacting Protein 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0024806
    Locus tag
    Dmel_CG7020
    See related
    AllianceGenome:FB:FBgn0024806
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG7020; Ddip2; Dmel\CG7020
    Summary
    Predicted to enable acetate-CoA ligase activity. Involved in axon guidance. Located in plasma membrane. Is expressed in several structures, including adult head; ganglia; spermatozoon; and visceral mesoderm. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder. Orthologous to human DIP2A (disco interacting protein 2 homolog A); DIP2B (disco interacting protein 2 homolog B); and DIP2C (disco interacting protein 2 homolog C). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See DIP2 in Genome Data Viewer
    Location:
    61B3-61B3; 3-1 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (250229..257954, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (250229..257954, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Enhancer of bithorax Neighboring gene methuselah-like 14 Neighboring gene ncRNA Neighboring gene Tudor staphylococcal nuclease Neighboring gene wee Augmin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. DIP2 is a unique regulator of diacylglycerol lipid homeostasis in eukaryotes. Mondal S, et al. Elife, 2022 Jun 29. PMID 35766356, Free PMC Article
    2. Identification of glaikit in a genome-wide expression profiling for axonal bifurcation of the mushroom body in Drosophila. Nitta Y, et al. Biochem Biophys Res Commun, 2017 Jun 10. PMID 28465232
    3. DISCO Interacting Protein 2 regulates axonal bifurcation and guidance of Drosophila mushroom body neurons. Nitta Y, et al. Dev Biol, 2017 Jan 15. PMID 27908785
    4. Cloning, genomic organization and expression pattern of a novel Drosophila gene, the disco-interacting protein 2 (dip2), and its murine homolog. Mukhopadhyay M, et al. Gene, 2002 Jun 26. PMID 12137943
    5. DISCO interacting protein 2 determines direction of axon projection under the regulation of c-Jun N-terminal kinase in the Drosophila mushroom body. Nitta Y, et al. Biochem Biophys Res Commun, 2017 May 20. PMID 28396149

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Here we show that DISCO interacting protein 2 (DIP2) is required for the accurate direction of axonal guidance.
      Title: DISCO interacting protein 2 determines direction of axon projection under the regulation of c-Jun N-terminal kinase in the Drosophila mushroom body.
    2. These results reveal a function of DIP2 in the developing nervous system and provide a potential functional relationship between fatty acid metabolism and axon morphogenesis.
      Title: DISCO Interacting Protein 2 regulates axonal bifurcation and guidance of Drosophila mushroom body neurons.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables acetate-CoA ligase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in acetyl-CoA biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    DISCO interacting protein 2
    Names
    CG7020-PA
    CG7020-PB
    CG7020-PC
    CG7020-PD
    CG7020-PE
    DIP2-PA
    DIP2-PB
    DIP2-PC
    DIP2-PD
    DIP2-PE
    NP_001246530.1
    NP_001261191.1
    NP_001261192.1
    NP_001261193.1
    NP_612019.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      250229..257954 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001259601.2 → NP_001246530.1  DISCO interacting protein 2, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246530.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9NDW1
      Conserved Domains (6) summary
      cd05905
      Location:469 → 1053
      Dip2; Disco-interacting protein 2 (Dip2)
      COG5068
      Location:33 → 368
      ARG80; Regulator of arginine metabolism and related MADS box-containing transcription factors [Transcription]
      PRK09192
      Location:469 → 1060
      PRK09192; acyl-CoA synthetase; Validated
      pfam00501
      Location:1124 → 1569
      AMP-binding; AMP-binding enzyme
      pfam06464
      Location:3 → 115
      DMAP_binding; DMAP1-binding Domain
      cl17068
      Location:1141 → 1744
      AFD_class_I; Adenylate forming domain, Class I superfamily

    2. NM_001274263.1 → NP_001261192.1  DISCO interacting protein 2, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261192.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PBG6
      Conserved Domains (6) summary
      cd05905
      Location:469 → 1053
      Dip2; Disco-interacting protein 2 (Dip2)
      COG5068
      Location:33 → 368
      ARG80; Regulator of arginine metabolism and related MADS box-containing transcription factors [Transcription]
      PRK09192
      Location:469 → 1060
      PRK09192; acyl-CoA synthetase; Validated
      pfam00501
      Location:1141 → 1586
      AMP-binding; AMP-binding enzyme
      pfam06464
      Location:3 → 115
      DMAP_binding; DMAP1-binding Domain
      cl17068
      Location:1158 → 1761
      AFD_class_I; Adenylate forming domain, Class I superfamily

    3. NM_001274262.1 → NP_001261191.1  DISCO interacting protein 2, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261191.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PGJ0
      Conserved Domains (6) summary
      cd05905
      Location:470 → 1054
      Dip2; Disco-interacting protein 2 (Dip2)
      COG5068
      Location:33 → 369
      ARG80; Regulator of arginine metabolism and related MADS box-containing transcription factors [Transcription]
      PRK09192
      Location:470 → 1061
      PRK09192; acyl-CoA synthetase; Validated
      pfam00501
      Location:1125 → 1570
      AMP-binding; AMP-binding enzyme
      pfam06464
      Location:3 → 115
      DMAP_binding; DMAP1-binding Domain
      cl17068
      Location:1142 → 1745
      AFD_class_I; Adenylate forming domain, Class I superfamily

    4. NM_001274264.1 → NP_001261193.1  DISCO interacting protein 2, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261193.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PDH5
      Conserved Domains (6) summary
      cd05905
      Location:470 → 1054
      Dip2; Disco-interacting protein 2 (Dip2)
      COG5068
      Location:33 → 369
      ARG80; Regulator of arginine metabolism and related MADS box-containing transcription factors [Transcription]
      PRK09192
      Location:470 → 1061
      PRK09192; acyl-CoA synthetase; Validated
      pfam00501
      Location:1142 → 1581
      AMP-binding; AMP-binding enzyme
      pfam06464
      Location:3 → 115
      DMAP_binding; DMAP1-binding Domain
      cl17068
      Location:1159 → 1756
      AFD_class_I; Adenylate forming domain, Class I superfamily

    5. NM_138175.4 → NP_612019.2  DISCO interacting protein 2, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_612019.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9NGP2, Q9W0S9
      Related
      FBpp0072420
      Conserved Domains (6) summary
      cd05905
      Location:470 → 1054
      Dip2; Disco-interacting protein 2 (Dip2)
      COG5068
      Location:33 → 369
      ARG80; Regulator of arginine metabolism and related MADS box-containing transcription factors [Transcription]
      PRK09192
      Location:470 → 1061
      PRK09192; acyl-CoA synthetase; Validated
      pfam00501
      Location:1142 → 1587
      AMP-binding; AMP-binding enzyme
      pfam06464
      Location:3 → 115
      DMAP_binding; DMAP1-binding Domain
      cl17068
      Location:1159 → 1762
      AFD_class_I; Adenylate forming domain, Class I superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9NDW1 M9NDW1
    M9PBG6 M9PBG6
    M9PDH5 M9PDH5
    M9PGJ0 M9PGJ0
    Q8MRM9 Q8MRM9
    Q9W0S9.2 Q9W0S9

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