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    Ada Adenosine deaminase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41092, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Adaprovided by FlyBase
    Official Full Name
    Adenosine deaminaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0037661
    Locus tag
    Dmel_CG11994
    See related
    AllianceGenome:FB:FBgn0037661
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    ada; ADA; CG11994; dADA; DmADA; Dmel\CG11994; DrosADA
    Summary
    Predicted to enable adenosine deaminase activity. Predicted to be involved in adenosine catabolic process and inosine biosynthetic process. Orthologous to human MAPDA (N6-Methyl-AMP deaminase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Ada in Genome Data Viewer
    Location:
    85C4-85C4; 3-48 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (9065183..9066303)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (4890905..4892025)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene NAD-dependent methylenetetrahydrofolate dehydrogenase Neighboring gene Mst85C Neighboring gene Lysine demethylase 2 Neighboring gene beag Neighboring gene pumilio Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45196

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Oxygenation and adenosine deaminase support growth and proliferation of ex vivo cultured Drosophila wing imaginal discs. Strassburger K, et al. Development, 2017 Jul 1. PMID 28526754
    2. A developmental genetic analysis of the lysine demethylase KDM2 mutations in Drosophila melanogaster. Zheng Y, et al. Mech Dev, 2014 Aug. PMID 25016215, Free PMC Article
    3. PRPS-Associated Disorders and the Drosophila Model of Arts Syndrome. Delos Santos K, et al. Int J Mol Sci, 2020 Jul 8. PMID 32650483, Free PMC Article
    4. Expression of Drosophila adenosine deaminase in immune cells during inflammatory response. Novakova M, et al. PLoS One, 2011 Mar 11. PMID 21412432, Free PMC Article
    5. Adenosine deaminase-related growth factors stimulate cell proliferation in Drosophila by depleting extracellular adenosine. Zurovec M, et al. Proc Natl Acad Sci U S A, 2002 Apr 2. PMID 11904370, Free PMC Article

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. both oxygenation of the tissue and adenosine deaminase activity in the medium support both growth and proliferation of wing discs.
      Title: Oxygenation and adenosine deaminase support growth and proliferation of ex vivo cultured Drosophila wing imaginal discs.
    2. Extra-cellular adenosine may function as a signal for energy allocation during immune response.
      Title: Expression of Drosophila adenosine deaminase in immune cells during inflammatory response.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables adenosine deaminase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables deaminase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in adenosine catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in inosine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    adenosine deaminase
    Names
    Ada-PA
    CG11994-PA
    NP_649866.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      9065183..9066303
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_141609.3 → NP_649866.1  adenosine deaminase [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649866.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A8E767, Q9VHH7
      Related
      FBpp0081451
      Conserved Domains (1) summary
      cd00443
      Location:8 → 327
      ADA_AMPD; Adenosine/AMP deaminase. Adenosine deaminases (ADAs) are present in pro- and eukaryotic organisms and catalyze the zinc dependent irreversible deamination of adenosine nucleosides to inosine nucleosides and ammonia. The eukaryotic AMP deaminase ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VHH7.1 Q9VHH7

    Gene LinkOut

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