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    Gabat gamma-aminobutyric acid transaminase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40188, updated on 17-Dec-2024

    Summary

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    Official Symbol
    Gabatprovided by FlyBase
    Official Full Name
    gamma-aminobutyric acid transaminaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0036927
    Locus tag
    Dmel_CG7433
    See related
    AllianceGenome:FB:FBgn0036927
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    149085_at; CG7433; Dmel\CG7433; GABA; gabat; GABAT; Q9VW68
    Summary
    Predicted to enable 4-aminobutyrate:2-oxoglutarate transaminase activity and pyridoxal phosphate binding activity. Involved in regulation of carbohydrate metabolic process; regulation of circadian sleep/wake cycle; and regulation of glutamate metabolic process. Located in mitochondrion. Is expressed in several structures, including embryonic/larval midgut primordium; ganglia; glial cell; gut section; and mesoderm. Human ortholog(s) of this gene implicated in Alzheimer's disease; GABA aminotransferase deficiency; and Huntington's disease. Orthologous to human ABAT (4-aminobutyrate aminotransferase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Gabat in Genome Data Viewer
    Location:
    76D8-76E1; 3-46 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (19997714..20000686, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (19990814..19993786, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR45161 Neighboring gene flightin Neighboring gene uncharacterized protein Neighboring gene Neurocalcin Neighboring gene Translocase of outer membrane 20 Neighboring gene uncharacterized protein Neighboring gene kugelei

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Medulloblastoma uses GABA transaminase to survive in the cerebrospinal fluid microenvironment and promote leptomeningeal dissemination. Martirosian V, et al. Cell Rep, 2021 Jun 29. PMID 34192534, Free PMC Article
    2. Sleep loss impairs intestinal stem cell function and gut homeostasis through the modulation of the GABA signalling pathway in Drosophila. Zhou J, et al. Cell Prolif, 2023 Sep. PMID 36869584, Free PMC Article
    3. A neuron-glia interaction involving GABA transaminase contributes to sleep loss in sleepless mutants. Chen WF, et al. Mol Psychiatry, 2015 Feb. PMID 24637426, Free PMC Article
    4. Recurrent architecture for adaptive regulation of learning in the insect brain. Eschbach C, et al. Nat Neurosci, 2020 Apr. PMID 32203499, Free PMC Article
    5. Independent Effects of γ-Aminobutyric Acid Transaminase (GABAT) on Metabolic and Sleep Homeostasis. Maguire SE, et al. J Biol Chem, 2015 Aug 14. PMID 26124278, Free PMC Article

    See all (55) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Medulloblastoma uses GABA transaminase to survive in the cerebrospinal fluid microenvironment and promote leptomeningeal dissemination.
      Title: Medulloblastoma uses GABA transaminase to survive in the cerebrospinal fluid microenvironment and promote leptomeningeal dissemination.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables 4-aminobutyrate:2-oxoglutarate transaminase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables pyridoxal phosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables pyridoxal phosphate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in gamma-aminobutyric acid catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in gamma-aminobutyric acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of carbohydrate metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of circadian sleep/wake cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of glutamate metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrial matrix ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    gamma-aminobutyric acid transaminase
    Names
    CG7433-PA
    CG7433-PB
    CG7433-PC
    CG7433-PD
    GABA transaminase
    Gabat-PA
    Gabat-PB
    Gabat-PC
    Gabat-PD
    Gamma-aminobutyric acid transaminase isoform A
    gamma aminobutyric acid
    gamma aminobutyric acid transaminase
    NP_001163479.1
    NP_001287125.1
    NP_649168.2
    NP_730476.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      19997714..20000686 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001170008.1 → NP_001163479.1  gamma-aminobutyric acid transaminase, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163479.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MYV0, Q9VW68
      Conserved Domains (2) summary
      COG0160
      Location:27 → 484
      GabT; 4-aminobutyrate aminotransferase or related aminotransferase [Amino acid transport and metabolism]
      cl18945
      Location:27 → 483
      AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...

    2. NM_168829.3 → NP_730476.1  gamma-aminobutyric acid transaminase, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_730476.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MYV0, Q9VW68
      Related
      FBpp0074677
      Conserved Domains (2) summary
      COG0160
      Location:27 → 484
      GabT; 4-aminobutyrate aminotransferase or related aminotransferase [Amino acid transport and metabolism]
      cl18945
      Location:27 → 483
      AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...

    3. NM_140911.4 → NP_649168.2  gamma-aminobutyric acid transaminase, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649168.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MYV0, Q9VW68
      Related
      FBpp0074678
      Conserved Domains (2) summary
      COG0160
      Location:27 → 484
      GabT; 4-aminobutyrate aminotransferase or related aminotransferase [Amino acid transport and metabolism]
      cl18945
      Location:27 → 483
      AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...

    4. NM_001300196.1 → NP_001287125.1  gamma-aminobutyric acid transaminase, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287125.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MYV0, Q9VW68
      Conserved Domains (2) summary
      COG0160
      Location:27 → 484
      GabT; 4-aminobutyrate aminotransferase or related aminotransferase [Amino acid transport and metabolism]
      cl18945
      Location:27 → 483
      AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8MYV0 Q8MYV0
    Q9VW68 Q9VW68

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