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    Acbp4 Acyl-CoA binding protein 4 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38781, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Acbp4provided by FlyBase
    Official Full Name
    Acyl-CoA binding protein 4provided by FlyBase
    Primary source
    FLYBASE:FBgn0035742
    Locus tag
    Dmel_CG8629
    See related
    AllianceGenome:FB:FBgn0035742
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    ACBP; BcDNA:RE33457; CG8629; DmCG8629; Dmel\CG8629
    Summary
    Predicted to enable fatty-acyl-CoA binding activity. Predicted to be involved in fatty acid metabolic process. Is expressed in gastric caecum. Human ortholog(s) of this gene implicated in alcohol dependence. Orthologous to human ACBD7 (acyl-CoA binding domain containing 7) and DBI (diazepam binding inhibitor, acyl-CoA binding protein). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Acbp4 in Genome Data Viewer
    Location:
    65E4-65E4; 3-19 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (7127913..7128264, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (7121013..7121364, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Cuticular protein 65Ec Neighboring gene formin 3 Neighboring gene male-specific lethal 3 Neighboring gene Bardet-Biedl syndrome 1 Neighboring gene Acyl-CoA binding protein 6 Neighboring gene Acyl-CoA binding protein 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. New insights into the functions of ACBD4/5-like proteins using a combined phylogenetic and experimental approach across model organisms. Kors S, et al. Biochim Biophys Acta Mol Cell Res, 2024 Dec. PMID 39271061
    2. The ACBP gene family in Rhodnius prolixus: Expression, characterization and function of RpACBP-1. Majerowicz D, et al. Insect Biochem Mol Biol, 2016 May. PMID 27001070
    3. Quality of regulatory elements in Drosophila retrogenes. Bai Y, et al. Genomics, 2009 Jan. PMID 18848618, Free PMC Article
    4. A distinct Acyl-CoA binding protein (ACBP6) shapes tissue plasticity during nutrient adaptation in Drosophila. Li X, et al. Nat Commun, 2023 Nov 21. PMID 37989752, Free PMC Article
    5. Evolution of the acyl-CoA binding protein (ACBP). Burton M, et al. Biochem J, 2005 Dec 1. PMID 16018771, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables fatty-acyl-CoA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables fatty-acyl-CoA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in fatty acid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Acyl-CoA binding protein 4
    Names
    Acbp4-PA
    CG8629-PA
    acyl-CoA-binding protein

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      7127913..7128264 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_139824.3 → NP_648081.1  Acyl-CoA binding protein 4 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648081.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VS20
      Related
      FBpp0076634
      Conserved Domains (1) summary
      pfam00887
      Location:4 → 81
      ACBP; Acyl CoA binding protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VS20 Q9VS20

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