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    GPHR Golgi pH Regulator [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36682, updated on 9-Dec-2024

    Summary

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    Official Symbol
    GPHRprovided by FlyBase
    Official Full Name
    Golgi pH Regulatorprovided by FlyBase
    Primary source
    FLYBASE:FBgn0033995
    Locus tag
    Dmel_CG8090
    See related
    AllianceGenome:FB:FBgn0033995
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG8090; dGPHR; Dmel\CG8090
    Summary
    Enables voltage-gated monoatomic anion channel activity. Involved in Golgi organization; intracellular pH reduction; and secretion by cell. Located in endoplasmic reticulum. Orthologous to human GPR89A (G protein-coupled receptor 89A) and GPR89B (G protein-coupled receptor 89B). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See GPHR in Genome Data Viewer
    Location:
    51E5-51E5; 2-74 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (15199065..15201200, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (11086570..11088705, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Seminal fluid protein 51E Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Ionotropic receptor 51a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mutations in the Drosophila ortholog of the vertebrate Golgi pH regulator (GPHR) protein disturb endoplasmic reticulum and Golgi organization and affect systemic growth. Charroux B, et al. Biol Open, 2014 Jan 15. PMID 24357227, Free PMC Article
    2. Anion-sensitive fluorophore identifies the Drosophila swell-activated chloride channel in a genome-wide RNA interference screen. Stotz SC, et al. PLoS One, 2012. PMID 23056495, Free PMC Article
    3. Investigating the genetic circuitry of mastermind in Drosophila, a notch signal effector. Kankel MW, et al. Genetics, 2007 Dec. PMID 18073442, Free PMC Article
    4. Genome-wide association analysis of oxidative stress resistance in Drosophila melanogaster. Weber AL, et al. PLoS One, 2012. PMID 22496853, Free PMC Article
    5. In vivo profiling of the Zucchini proximal proteome in the Drosophila ovary. Nguyen TTM, et al. Development, 2023 Feb 15. PMID 36762624

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables voltage-gated monoatomic anion channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables voltage-gated monoatomic anion channel activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Golgi organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular pH reduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular pH reduction IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in secretion by cell IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in Golgi cisterna membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    golgi pH regulator
    Names
    CG8090-PA
    GPHR-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      15199065..15201200 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_137172.4 → NP_611016.2  golgi pH regulator [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611016.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z9Y2, Q3ZAN1
      Conserved Domains (2) summary
      pfam12430
      Location:277 → 443
      ABA_GPCR; Abscisic acid G-protein coupled receptor
      pfam12537
      Location:141 → 208
      GPHR_N; The Golgi pH Regulator (GPHR) Family N-terminal
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3ZAN1 Q3ZAN1

    Gene LinkOut

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