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    SCAP SREBP cleavage activating protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35529, updated on 9-Dec-2024

    Summary

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    Official Symbol
    SCAPprovided by FlyBase
    Official Full Name
    SREBP cleavage activating proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0033052
    Locus tag
    Dmel_CG33131
    See related
    AllianceGenome:FB:FBgn0033052
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG14592; CG33131; CG8356; Dmel\CG33131; dscap; dScap; dSCAP; Scap; Scap_Dm
    Summary
    Predicted to enable sterol binding activity. Predicted to be involved in regulation of cholesterol biosynthetic process. Predicted to be located in Golgi membrane. Predicted to be part of SREBP-SCAP complex. Predicted to be active in endoplasmic reticulum membrane. Is expressed in adult head. Orthologous to human SCAP (SREBF chaperone). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See SCAP in Genome Data Viewer
    Location:
    42A8-42A8; 2-55 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (6026273..6036388, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (1913778..1923893, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Actin 42A Neighboring gene PNGase-like Neighboring gene Ser/Thr-rich caspase Neighboring gene uncharacterized protein Neighboring gene Tubulin-binding cofactor E

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cell biology. Fats, flies, and palmitate. Nohturfft A, et al. Science, 2002 May 3. PMID 11988558
    2. Reconstitution of sterol-regulated endoplasmic reticulum-to-Golgi transport of SREBP-2 in insect cells by co-expression of mammalian SCAP and Insigs. Dobrosotskaya IY, et al. J Biol Chem, 2003 Sep 12. PMID 12842885
    3. Other ways to skin a cat: activating SREBP without Scap. Ozdemir C, et al. Fly (Austin), 2011 Jan-Mar. PMID 20935466, Free PMC Article
    4. Fatty acid auxotrophy in Drosophila larvae lacking SREBP. Kunte AS, et al. Cell Metab, 2006 Jun. PMID 16753579
    5. The SREBP pathway--insights from Insigs and insects. Rawson RB. Nat Rev Mol Cell Biol, 2003 Aug. PMID 12923525

    See all (47) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    mobile_element

    • Loc: c6030851-6030250 mobile_element_type = transposon:INE-1{}6213

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables sterol binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in SREBP signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of cholesterol biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of SREBP-SCAP complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    SREBP cleavage activating protein
    Names
    CG33131-PA
    SCAP-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      6026273..6036388 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_176097.3 → NP_788277.1  SREBP cleavage activating protein [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788277.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z6J2, Q8N0B6
      Related
      FBpp0085363
      Conserved Domains (4) summary
      COG2319
      Location:878 → 1227
      WD40; WD40 repeat [General function prediction only]
      pfam12349
      Location:390 → 542
      Sterol-sensing; Sterol-sensing domain of SREBP cleavage-activation
      sd00039
      Location:1079 → 1114
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:878 → 1185
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1Z6J2 A1Z6J2
    Q8MRU6 Q8MRU6
    Q8N0B6 Q8N0B6

    Gene LinkOut

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