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    CG43366 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35519, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG43366provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0263109
    Locus tag
    Dmel_CG43366
    See related
    AllianceGenome:FB:FBgn0263109
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG12551; CG14470; Dmel\CG43366
    Old locus tag
    Dmel_CG12551; Dmel_CG14470
    Summary
    Predicted to be active in extracellular space. Is expressed in several structures, including embryonic anal pad; embryonic epipharynx; embryonic hypopharynx; epithelial tube; and gut section. Human ortholog(s) of this gene implicated in several diseases, including bone disease (multiple); brain edema; eye disease (multiple); leukostasis; and metabolic dysfunction-associated steatohepatitis. Orthologous to human SERPINF1 (serpin family F member 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG43366 in Genome Data Viewer
    Location:
    42A2-42A4; 2-55 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (5893895..5931363)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (1781400..1818868)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44125 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44126 Neighboring gene antisense RNA:CR46269 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Evolution of Plasticity in Response to Ethanol between Sister Species with Different Ecological Histories (Drosophila melanogaster and D. simulans). Signor SA. Am Nat, 2020 Nov. PMID 33064591
    2. A novel method for quantifying the rate of embryogenesis uncovers considerable genetic variation for the duration of embryonic development in Drosophila melanogaster. Horváth B, et al. BMC Evol Biol, 2016 Oct 7. PMID 27717305, Free PMC Article
    3. The Drosophila serpins: multiple functions in immunity and morphogenesis. Reichhart JM, et al. Methods Enzymol, 2011. PMID 21683256
    4. A Balance of Yki/Sd Activator and E2F1/Sd Repressor Complexes Controls Cell Survival and Affects Organ Size. Zhang P, et al. Dev Cell, 2017 Dec 4. PMID 29207260, Free PMC Article
    5. Molecular landscape of modified histones in Drosophila heterochromatic genes and euchromatin-heterochromatin transition zones. Yasuhara JC, et al. PLoS Genet, 2008 Jan. PMID 18208336, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    mobile_element

    • Loc: 5923565-5924639 mobile_element_type = transposon:jockey{}5749

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    NOT enables serine-type endopeptidase inhibitor activity IKR
    Inferred from Key Residues
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG43366-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      5893895..5931363
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136344.3 → NP_610188.2  uncharacterized protein Dmel_CG43366 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610188.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z6I3
      Conserved Domains (1) summary
      cl00137
      Location:1687 → 2136
      SERPIN; SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1Z6I3 A1Z6I3

    Gene LinkOut

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