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    firl firelighter [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34627, updated on 9-Dec-2024

    Summary

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    Official Symbol
    firlprovided by FlyBase
    Official Full Name
    firelighterprovided by FlyBase
    Primary source
    FLYBASE:FBgn0032405
    Locus tag
    Dmel_CG14946
    See related
    AllianceGenome:FB:FBgn0032405
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG14946; Dmel\CG14946
    Summary
    Predicted to enable oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor. Predicted to be active in lipid droplet. Is expressed in adult head. Orthologous to human HSD17B11 (hydroxysteroid 17-beta dehydrogenase 11); HSD17B13 (hydroxysteroid 17-beta dehydrogenase 13); and RDH10 (retinol dehydrogenase 10). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See firl in Genome Data Viewer
    Location:
    33C2-33C2; 2-46 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (12063457..12066775, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (12063457..12066775, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Ribosomal protein L7-like Neighboring gene uncharacterized protein Neighboring gene Rab3 GTPase activating protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44591

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Active promoters and insulators are marked by the centrosomal protein 190. Bartkuhn M, et al. EMBO J, 2009 Apr 8. PMID 19229299, Free PMC Article
    2. Transcriptome analysis provides insights for understanding the adverse effects of endosulfan in Drosophila melanogaster. Sharma A, et al. Chemosphere, 2011 Jan. PMID 21036383
    3. Analysis of the eye developmental pathway in Drosophila using DNA microarrays. Michaut L, et al. Proc Natl Acad Sci U S A, 2003 Apr 1. PMID 12655063, Free PMC Article
    4. Profiling of the muscle-specific dystroglycan interactome reveals the role of Hippo signaling in muscular dystrophy and age-dependent muscle atrophy. Yatsenko AS, et al. BMC Med, 2020 Jan 21. PMID 31959160, Free PMC Article
    5. RNAseq analysis of the drug jian-yan-ling (JYL) using both in vivo and in vitro models. Zhang X, et al. Heliyon, 2023 May. PMID 37251843, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in lipid droplet IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    firelighter
    Names
    CG14946-PC
    CG14946-PD
    CG14946-PE
    firl-PC
    firl-PD
    firl-PE
    NP_001033900.2
    NP_001245997.1
    NP_001285867.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      12063457..12066775 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001259068.2 → NP_001245997.1  firelighter, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245997.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q5BID6, Q9VKB8
      Conserved Domains (2) summary
      cd05339
      Location:57 → 299
      17beta-HSDXI-like_SDR_c; human 17-beta-hydroxysteroid dehydrogenase XI-like, classical (c) SDRs
      pfam00106
      Location:56 → 246
      adh_short; short chain dehydrogenase

    2. NM_001298938.1 → NP_001285867.1  firelighter, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285867.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q5BID6, Q9VKB8
      Conserved Domains (2) summary
      cd05339
      Location:57 → 299
      17beta-HSDXI-like_SDR_c; human 17-beta-hydroxysteroid dehydrogenase XI-like, classical (c) SDRs
      pfam00106
      Location:56 → 246
      adh_short; short chain dehydrogenase

    3. NM_001038811.3 → NP_001033900.2  firelighter, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001033900.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q5BID6, Q9VKB8
      Conserved Domains (2) summary
      cd05339
      Location:57 → 299
      17beta-HSDXI-like_SDR_c; human 17-beta-hydroxysteroid dehydrogenase XI-like, classical (c) SDRs
      pfam00106
      Location:56 → 246
      adh_short; short chain dehydrogenase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5BID6 Q5BID6
    Q9VKB8 Q9VKB8

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