U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    CG2772 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33559, updated on 17-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    CG2772provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0031533
    Locus tag
    Dmel_CG2772
    See related
    AllianceGenome:FB:FBgn0031533
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:RE45077; Dmel\CG2772
    Summary
    Predicted to enable triacylglycerol lipase activity. Predicted to be involved in lipid metabolic process. Human ortholog(s) of this gene implicated in Wolman disease; autosomal recessive congenital ichthyosis 8; and cholesterol ester storage disease. Orthologous to several human genes including LIPA (lipase A, lysosomal acid type); LIPF (lipase F, gastric type); and LIPJ (lipase family member J). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See CG2772 in Genome Data Viewer
    Location:
    23F3-23F3; 2-10 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (3445992..3447589)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (3445992..3447589)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Polypeptide N-Acetylgalactosaminyltransferase 2 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Sorting nexin 1 Neighboring gene uncharacterized protein Neighboring gene Component of oligomeric golgi complex 3

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Drosophila HNF4 acts in distinct tissues to direct a switch between lipid storage and export in the gut. Vonolfen MC, et al. Cell Rep, 2024 Sep 24. PMID 39235946
    2. Drosophila melanogaster tPlus3a and tPlus3b ensure full male fertility by regulating transcription of Y-chromosomal, seminal fluid, and heat shock genes. Hundertmark T, et al. PLoS One, 2019. PMID 30845228, Free PMC Article
    3. Control of lipid metabolism by tachykinin in Drosophila. Song W, et al. Cell Rep, 2014 Oct 9. PMID 25263556, Free PMC Article
    4. Germline-dependent gene expression in distant non-gonadal somatic tissues of Drosophila. Parisi MJ, et al. BMC Genomics, 2010 Jun 1. PMID 20515475, Free PMC Article
    5. Auxin exposure disrupts feeding behavior and fatty acid metabolism in adult Drosophila. Fleck SA, et al. Elife, 2024 Jan 19. PMID 38240746, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables hydrolase activity, acting on ester bonds IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables triacylglycerol lipase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    uncharacterized protein
    Names
    CG2772-PA
    NP_608776.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      3445992..3447589
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_134932.3 → NP_608776.1  uncharacterized protein Dmel_CG2772 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_608776.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VQQ5
      Related
      FBpp0077205
      Conserved Domains (3) summary
      PLN02872
      Location:5 → 393
      PLN02872; triacylglycerol lipase
      pfam04083
      Location:36 → 103
      Abhydro_lipase; Partial alpha/beta-hydrolase lipase region
      cl21494
      Location:113 → 196
      Abhydrolase; alpha/beta hydrolases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VQQ5 Q9VQQ5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools