U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    TfAP-2 Transcription factor AP-2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40398, updated on 17-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    TfAP-2provided by FlyBase
    Official Full Name
    Transcription factor AP-2provided by FlyBase
    Primary source
    FLYBASE:FBgn0261953
    Locus tag
    Dmel_CG7807
    See related
    AllianceGenome:FB:FBgn0261953
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    AP-2; AP-2alpha; CG7807; dAP-2; DAP-2; dAP-2alpha; Dmel\CG7807; dTfap2; l(3)1215; tfAP-2; Tfap-2; TfaP-2; Tfap2
    Summary
    Enables DNA-binding transcription factor activity and sequence-specific DNA binding activity. Involved in several processes, including adult feeding behavior; imaginal disc-derived leg joint morphogenesis; and regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including adult Pdf neurons; brain; ganglia; head epidermis primordium; and imaginal disc. Used to study sleep disorder. Human ortholog(s) of this gene implicated in Char syndrome; branchiooculofacial syndrome; and patent ductus arteriosus. Orthologous to several human genes including TFAP2A (transcription factor AP-2 alpha); TFAP2B (transcription factor AP-2 beta); and TFAP2D (transcription factor AP-2 delta). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See TfAP-2 in Genome Data Viewer
    Location:
    78D7-78E1; 3-47 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (21586828..21613349)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (21579928..21606449)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR43939 Neighboring gene hairpin RNA:CR46340 Neighboring gene ER membrane protein complex subunit 10 Neighboring gene long non-coding RNA:CR43940 Neighboring gene Site-1 protease Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Cloning and characterization of the Drosophila homologue of the AP-2 transcription factor. Bauer R, et al. Oncogene, 1998 Oct 15. PMID 9788434
    2. DAP-2, the Drosophila homolog of transcription factor AP-2. Monge I, et al. Mech Dev, 1998 Aug. PMID 9867351
    3. Characterization of the activation domains of AP-2 family transcription factors. Wankhade S, et al. J Biol Chem, 2000 Sep 22. PMID 10899156
    4. TfAP-2 is required for night sleep in Drosophila. Kucherenko MM, et al. BMC Neurosci, 2016 Nov 9. PMID 27829368, Free PMC Article
    5. Specificity of the Hox member Deformed is determined by transcription factor levels and binding site affinities. Pinto PB, et al. Nat Commun, 2022 Aug 26. PMID 36028502, Free PMC Article

    See all (83) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Results show that AP2 is crucially required for night sleep in Drosophila. Despite regulating larval development, AP2 is also required in the adult brain for sleep control. Thus, work shows that AP2 transcription factors are conserved regulators of sleep and this work thus provides strong support for a common evolutionary origin of sleep-controlling mechanism.
      Title: TfAP-2 is required for night sleep in Drosophila.
    2. genetically manipulating the obesity-linked homologs TfAP-2 and Twz is sufficient to affect octopamine signaling, which in turn modulates Drosophila male behavior through the regulation of the satiation hormone Dsk.
      Title: Regulation of aggression by obesity-linked genes TfAP-2 and Twz through octopamine signaling in Drosophila.
    3. AP-2, is required for outgrowth of leg and antennal segments and is expressed in every segment boundary during development.
      Title: Segment-specific regulation of the Drosophila AP-2 gene during leg and antennal development.
    4. AP-2 and defective proventriculus regulate Serrate and Delta expression in the tarsus of Drosophila melanogaster.
      Title: dAP-2 and defective proventriculus regulate Serrate and Delta expression in the tarsus of Drosophila melanogaster.
    5. Data show that the endocytic adapter protein AP-2 is essential for rhodopsin endocytosis through an arrestin2-AP-2beta interaction.
      Title: An essential role for endocytosis of rhodopsin through interaction of visual arrestin with the AP-2 adaptor.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Notch signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in adult feeding behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in adult locomotory behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in imaginal disc-derived leg joint morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in imaginal disc-derived leg morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in imaginal disc-derived male genitalia development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in inter-male aggressive behavior IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in male courtship behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of octopamine signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in proboscis development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of cell population proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of circadian sleep/wake cycle, sleep IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    transcription factor AP-2
    Names
    AP-2
    CG7807-PA
    CG7807-PB
    CG7807-PC
    CG7807-PD
    CG7807-PE
    CG7807-PF
    TfAP-2-PA
    TfAP-2-PB
    TfAP-2-PC
    TfAP-2-PD
    TfAP-2-PE
    TfAP-2-PF
    lethal (3) 1215
    stummelbein

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      21586828..21613349
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001275251.1 → NP_001262180.1  transcription factor AP-2, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262180.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PFX8
      Conserved Domains (1) summary
      pfam03299
      Location:241 → 435
      TF_AP-2; Transcription factor AP-2

    2. NM_001275248.1 → NP_001262177.1  transcription factor AP-2, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262177.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PG57
      Conserved Domains (1) summary
      pfam03299
      Location:235 → 429
      TF_AP-2; Transcription factor AP-2

    3. NM_001275249.1 → NP_001262178.1  transcription factor AP-2, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262178.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PIH9
      Conserved Domains (1) summary
      pfam03299
      Location:247 → 441
      TF_AP-2; Transcription factor AP-2

    4. NM_141079.3 → NP_649336.1  transcription factor AP-2, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649336.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O96378
      Related
      FBpp0078072
      Conserved Domains (1) summary
      pfam03299
      Location:241 → 435
      TF_AP-2; Transcription factor AP-2

    5. NM_001275250.1 → NP_001262179.1  transcription factor AP-2, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262179.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PD85
      Conserved Domains (1) summary
      pfam03299
      Location:243 → 437
      TF_AP-2; Transcription factor AP-2

    6. NM_168927.2 → NP_730664.1  transcription factor AP-2, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_730664.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O76923
      Related
      FBpp0078073
      Conserved Domains (1) summary
      pfam03299
      Location:237 → 431
      TF_AP-2; Transcription factor AP-2
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PD85 M9PD85
    M9PFX8 M9PFX8
    M9PG57 M9PG57
    M9PIH9 M9PIH9
    O76923 O76923
    O96378 O96378

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous