ETH Ecdysis triggering hormone [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: ETHprovided by FlyBase
Official Full Name: Ecdysis triggering hormoneprovided by FlyBase
Primary source: FLYBASE:FBgn0028738
Locus tag: Dmel_CG18105
See related: AllianceGenome:FB:FBgn0028738
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG18105; Dmel\CG18105; DmETH; Drm-ETH-1; Drm-ETH-2; eth; Eth; ETH-1; ETH-2; ETH1; ETH2
Summary: Enables G protein-coupled receptor binding activity and ecdysis-triggering hormone activity. Involved in ecdysis, chitin-based cuticle and neuropeptide signaling pathway. Located in extracellular space. Is expressed in embryonic/larval peritracheal PM cell. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (24794670..24795482, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (20682193..20683005, complement)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

ETH is a dual regulator of octopamine and juvenile hormone release and its deficiency suppresses oogenesis and ovulation.
Title: Stress-induced reproductive arrest in Drosophila occurs through ETH deficiency-mediated suppression of oogenesis and ovulation.
Characterization of ecdysis triggering hormone in arthropods
Title: Ecdysis triggering hormone signaling in arthropods.

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables G protein-coupled receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables ecdysis-triggering hormone activity	IDA Inferred from Direct Assay more info	PubMed
enables ecdysis-triggering hormone activity	NAS Non-traceable Author Statement more info	PubMed
enables neuropeptide hormone activity	TAS Traceable Author Statement more info	PubMed
enables signaling receptor binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in ecdysis, chitin-based cuticle	IDA Inferred from Direct Assay more info	PubMed
involved_in ecdysis, chitin-based cuticle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuropeptide signaling pathway	IEP Inferred from Expression Pattern more info	PubMed
involved_in neuropeptide signaling pathway	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular space	IC Inferred by Curator more info	PubMed
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	ISM Inferred from Sequence Model more info

Names: CG18105-PA; ETH-PA; Ecdysis-triggering hormone; ecdysis triggering hormone 1; ecdysis triggering hormone-1; ecdysis triggering hormone-2; ecdysis-triggering hormone-1; ecdysis-triggering hormone-2; ecdysis-triggering-hormone-1