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    CG30259 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37606, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG30259provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0050259
    Locus tag
    Dmel_CG30259
    See related
    AllianceGenome:FB:FBgn0050259
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG13522; CG13523; Dmel\CG30259
    Summary
    Predicted to be involved in axonemal dynein complex assembly; cilium-dependent cell motility; and regulation of cilium movement. Predicted to be part of axonemal dynein complex. Predicted to be active in axoneme. Is expressed in chordotonal neurons and spermatozoon. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 27. Orthologous to human CCDC65 (coiled-coil domain containing 65). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG30259 in Genome Data Viewer
    Location:
    59A3-59A3; 2-101 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (22701345..22704447, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (18588850..18591952, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44764 Neighboring gene roundabout 1 Neighboring gene Odorant-binding protein 59a Neighboring gene Odorant-binding protein 58b Neighboring gene Odorant-binding protein 58c

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Selection, recombination and demographic history in Drosophila miranda. Bachtrog D, et al. Genetics, 2006 Dec. PMID 17028331, Free PMC Article
    2. Decoding cilia function: defining specialized genes required for compartmentalized cilia biogenesis. Avidor-Reiss T, et al. Cell, 2004 May 14. PMID 15137945
    3. Survey of the Ciliary Motility Machinery of Drosophila Sperm and Ciliated Mechanosensory Neurons Reveals Unexpected Cell-Type Specific Variations: A Model for Motile Ciliopathies. Zur Lage P, et al. Front Genet, 2019. PMID 30774648, Free PMC Article
    4. Genes conserved in bilaterians but jointly lost with Myc during nematode evolution are enriched in cell proliferation and cell migration functions. Erives AJ. Dev Genes Evol, 2015 Sep. PMID 26173873, Free PMC Article
    5. The genetic basis for variation in olfactory behavior in Drosophila melanogaster. Arya GH, et al. Chem Senses, 2015 May. PMID 25687947, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in axonemal dynein complex assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in axonemal dynein complex assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cilium-dependent cell motility IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of cilium movement IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of axonemal dynein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in axoneme IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG30259-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      22701345..22704447 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_137864.3 → NP_611708.2  uncharacterized protein Dmel_CG30259 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611708.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W212
      Conserved Domains (1) summary
      pfam14772
      Location:27 → 127
      NYD-SP28; Sperm tail
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9W212 Q9W212

    Gene LinkOut

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