Hsf Heat shock factor [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Hsfprovided by FlyBase
Official Full Name: Heat shock factorprovided by FlyBase
Primary source: FLYBASE:FBgn0001222
Locus tag: Dmel_CG5748
See related: AllianceGenome:FB:FBgn0001222
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG5748; D-HSF; dHSF; dHSF1; dHSFa; Dm-Hsf; Dmel\CG5748; DmHSF; DmHSFa; heat shock factor; hsf; HSF; hsf-1; hsf1; Hsf1; HSF1; HSFa; l(2)03091
Summary: Enables DNA-binding transcription factor activity and sequence-specific DNA binding activity. Involved in defense response to other organism; regulation of DNA-templated transcription; and response to heat. Located in chromatin; nucleus; and polytene chromosome. Is expressed in several structures, including embryonic/larval crystal cell; embryonic/larval midgut; embryonic/larval midgut primordium; and procrystal cell. Human ortholog(s) of this gene implicated in Huntington's disease; cataract; and cataract 5 multiple types. Orthologous to several human genes including HSF1 (heat shock transcription factor 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 55B7-55B8; 2-84 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (18130303..18134634, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (14017808..14022139, complement)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Azadiradione ameliorates polyglutamine expansion disease in Drosophila by potentiating DNA binding activity of heat shock factor 1.
Title: Azadiradione ameliorates polyglutamine expansion disease in Drosophila by potentiating DNA binding activity of heat shock factor 1.
HSF role in the heat shock response to viral infection
Title: The heat shock response restricts virus infection in Drosophila.
Knockdown of the Drosophila Nrf1 and Nrf2 ortholog cap 'n' collar isoform-C, but not Hsf1, blocks the protective effect of ASC-JM17 on mutant AR-induced eye degeneration in flies. Our observations indicate that activation of the Nrf1/Nrf2 pathway is a viable option for pharmacological intervention in SBMA and potentially other polyglutamine diseases.
Title: A small-molecule Nrf1 and Nrf2 activator mitigates polyglutamine toxicity in spinal and bulbar muscular atrophy.
HSF is dispensable for establishing or maintaining Pol II pausing but is critical for the release of paused Pol II into the gene body at a subset of highly activated genes
Title: Transcription factors GAF and HSF act at distinct regulatory steps to modulate stress-induced gene activation.
The survival curves of heterozygotes on hsf-1 and hsf-4 alleles are similar in spite of HSF-4 protein is slightly active on normal temperature.
Title: [VARIOUS ALLELES OF HSF HEAT-SHOCK TRANSCRIPTION FACTOR OF DROSOPHILA MELANOGASTER INCREASE VIABILITY OF ITS CARRIERS IN UNFAVORABLE ENVIRONMENTS].
Physiological function of mutated HSF4 is not fully abrogated after heat exposure and is able to recover even after severe heat stress, causing the induction of heat-shock gene expression.
Title: [Kinetics of heat shock response upon disfunction of general transcription factor (HSF)].
HSF1 and LGL interact during ontogenesis and stress-defending processes
Title: [Parallelism and paradoxes on viability and the life span of two loss-of-function mutations: heat shock protein transcriptional regulator hsf(1) and l(2)gl tumor suppressor in D. melanogaster].
HSF may be regulating many genes besides the known HS genes and that some of these genes may be regulated during non-stress conditions
Title: Whole-genome analysis reveals that active heat shock factor binding sites are mostly associated with non-heat shock genes in Drosophila melanogaster.
HSF binds to nmnat promoter and induces NMNAT expression under heat shock. In contrast, under hypoxia, HIF1alpha up-regulates NMNAT indirectly through the induction of HSF
Title: Nicotinamide mononucleotide adenylyltransferase is a stress response protein regulated by the heat shock factor/hypoxia-inducible factor 1alpha pathway.
Recruitment of the master regulator, HSF, is first detected within 20 s of gene activation.
Title: Recruitment timing and dynamics of transcription factors at the Hsp70 loci in living cells.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Dm0302 (e-PCR)
- UniSTS:52120

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA binding	TAS Traceable Author Statement more info	PubMed
enables DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in defense response to bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in defense response to fungus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of DNA-templated transcription	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in response to heat	IDA Inferred from Direct Assay more info	PubMed
involved_in response to heat	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to heat	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in chromatin	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in polytene chromosome	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: heat shock factor

Names: CG5748-PA; CG5748-PB; CG5748-PC; CG5748-PD; Heat-Shock factor; Hsf-PA; Hsf-PB; Hsf-PC; Hsf-PD; heat shock transcription factor; heat shock transcription factor 1; heat-shock transcription factor

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033778.4 Reference assembly

Range

18130303..18134634 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_057227.5 → NP_476575.1 heat shock factor, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_476575.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P22813, Q9V8C1

UniProtKB/TrEMBL

Q95TH9

Related

FBpp0085961

Conserved Domains (2) summary

smart00415
Location:45 → 148

HSF; heat shock factor

pfam06546
Location:583 → 669

Vert_HS_TF; Vertebrate heat shock transcription factor
NM_001043092.3 → NP_001036557.1 heat shock factor, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001036557.1

Status: REVIEWED

UniProtKB/TrEMBL

Q4H2F9, Q95TH9

Conserved Domains (2) summary

smart00415
Location:45 → 148

HSF; heat shock factor

pfam06546
Location:607 → 693

Vert_HS_TF; Vertebrate heat shock transcription factor
NM_001043090.3 → NP_001036555.1 heat shock factor, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001036555.1

Status: REVIEWED

UniProtKB/TrEMBL

Q4H2F7, Q95TH9

Conserved Domains (2) summary

smart00415
Location:45 → 148

HSF; heat shock factor

pfam06546
Location:607 → 711

Vert_HS_TF; Vertebrate heat shock transcription factor
NM_001043091.3 → NP_001036556.1 heat shock factor, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001036556.1

Status: REVIEWED

UniProtKB/TrEMBL

Q4H2F8, Q95TH9

Conserved Domains (2) summary

smart00415
Location:45 → 148

HSF; heat shock factor

pfam06546
Location:583 → 687

Vert_HS_TF; Vertebrate heat shock transcription factor

Nucleotide		Protein
Heading	Accession and Version	Protein

Protein Accession	Links
Protein Accession	GenPept Link	UniProtKB Link
P22813.1		P22813
Q4H2F7		Q4H2F7
Q4H2F8		Q4H2F8
Q4H2F9		Q4H2F9
Q867H6		Q867H6
Q86BZ1		Q86BZ1
Q86BZ2		Q86BZ2
Q86BZ3		Q86BZ3
Q86BZ4		Q86BZ4
Q86BZ5		Q86BZ5
Q95TH9		Q95TH9