Gdi GDP dissociation inhibitor [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Gdiprovided by FlyBase
Official Full Name: GDP dissociation inhibitorprovided by FlyBase
Primary source: FLYBASE:FBgn0004868
Locus tag: Dmel_CG4422
See related: AllianceGenome:FB:FBgn0004868
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: Bulli; CG4422; dGDI; Dmel\CG4422; gdi; GdI; GDI; l(2)N7-3; lincRNA.S746; N7-3; rab GDI
Summary: Enables GDP-dissociation inhibitor activity. Predicted to be involved in vesicle-mediated transport. Located in cytosol. Is expressed in several structures, including CNS glial cell; brain; gut section; head epidermis primordium; and sensory nervous system primordium. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability; non-syndromic X-linked intellectual disability 41; and psychotic disorder. Orthologous to human GDI1 (GDP dissociation inhibitor 1) and GDI2 (GDP dissociation inhibitor 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (9491176..9494876, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (9491176..9494876, complement)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables GDP-dissociation inhibitor activity	IDA Inferred from Direct Assay more info	PubMed
enables Rab GDP-dissociation inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info
enables Rab GDP-dissociation inhibitor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in neurotransmitter secretion	NAS Non-traceable Author Statement more info	PubMed
involved_in protein transport	IEA Inferred from Electronic Annotation more info
involved_in small GTPase-mediated signal transduction	IEA Inferred from Electronic Annotation more info
involved_in vesicle-mediated transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in vesicle-mediated transport	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	HDA more info	PubMed
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in synaptic vesicle	NAS Non-traceable Author Statement more info	PubMed

Names: CG4422-PA; CG4422-PB; CG4422-PC; Gdi-PA; Gdi-PB; Gdi-PC; Gdi-related; rab GDP dissociation inhibitor

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The following sections contain reference sequences that belong to a specific genome build. Explain