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    Spn42Dc Serpin 42Dc [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35600, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Spn42Dcprovided by FlyBase
    Official Full Name
    Serpin 42Dcprovided by FlyBase
    Primary source
    FLYBASE:FBgn0033113
    Locus tag
    Dmel_CG9455
    See related
    AllianceGenome:FB:FBgn0033113
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG9455; Dmel\CG9455
    Summary
    Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in negative regulation of proteolysis. Predicted to be active in extracellular space. Orthologous to human SERPINB1 (serpin family B member 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Spn42Dc in Genome Data Viewer
    Location:
    42D6-42D6; 2-55 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (6880995..6883407)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (2768500..2770912)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR44169 Neighboring gene Serpin 42Da Neighboring gene Serpin 42Db Neighboring gene Serpin 42Dd Neighboring gene Serpin 42De Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Drosophila serpins: multiple functions in immunity and morphogenesis. Reichhart JM, et al. Methods Enzymol, 2011. PMID 21683256
    2. Identification and analysis of serpin-family genes by homology and synteny across the 12 sequenced Drosophilid genomes. Garrett M, et al. BMC Genomics, 2009 Oct 22. PMID 19849829, Free PMC Article
    3. Molecular phylogeny of the antiangiogenic and neurotrophic serpin, pigment epithelium derived factor in vertebrates. Xu X, et al. BMC Genomics, 2006 Oct 4. PMID 17020603, Free PMC Article
    4. Fungal peptide Destruxin A plays a specific role in suppressing the innate immune response in Drosophila melanogaster. Pal S, et al. J Biol Chem, 2007 Mar 23. PMID 17227774
    5. Immunity-related genes and gene families in Anopheles gambiae. Christophides GK, et al. Science, 2002 Oct 4. PMID 12364793

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables serine-type endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of proteolysis ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    serpin 42Dc
    Names
    CG9455-PA
    CG9455-PB
    Spn42Dc-PA
    Spn42Dc-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      6880995..6883407
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001259225.2 → NP_001246154.1  serpin 42Dc, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246154.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z6R4
      Conserved Domains (1) summary
      cd00172
      Location:7 → 377
      SERPIN; SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate ...

    2. NM_136401.5 → NP_610245.2  serpin 42Dc, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610245.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z6R4
      Related
      FBpp0085495
      Conserved Domains (1) summary
      cd00172
      Location:7 → 377
      SERPIN; SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1Z6R4 A1Z6R4
    Q8T3Z2 Q8T3Z2

    Gene LinkOut

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