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    fng fringe [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40314, updated on 9-Dec-2024

    Summary

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    Official Symbol
    fngprovided by FlyBase
    Official Full Name
    fringeprovided by FlyBase
    Primary source
    FLYBASE:FBgn0011591
    Locus tag
    Dmel_CG10580
    See related
    AllianceGenome:FB:FBgn0011591
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG10580; D-fng; D-Fng; Dfng; Dmel\CG10580; fg; Fng; frg; Frg; Fringe; l(3)rG554
    Summary
    Enables O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity. Involved in several processes, including oogenesis; regionalization; and regulation of Notch signaling pathway. Located in Golgi medial cisterna and endoplasmic reticulum. Is expressed in several structures, including clypeo-labral primordium; epithelial cell; epithelium; gut section; and imaginal disc. Human ortholog(s) of this gene implicated in spondylocostal dysostosis 3. Orthologous to several human genes including LFNG (LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase) and MFNG (MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See fng in Genome Data Viewer
    Location:
    78A1-78A1; 3-47 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (20925891..20949512, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (20918991..20942612, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45734 Neighboring gene long non-coding RNA:CR43929 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45243 Neighboring gene Seminase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular genetic analysis of the glycosyltransferase Fringe in Drosophila. Correia T, et al. Proc Natl Acad Sci U S A, 2003 May 27. PMID 12743367, Free PMC Article
    2. Secreted fringe-like signaling molecules may be glycosyltransferases. Yuan YP, et al. Cell, 1997 Jan 10. PMID 9019410
    3. The notch signalling regulator fringe acts in the Golgi apparatus and requires the glycosyltransferase signature motif DXD. Munro S, et al. Curr Biol, 2000 Jul 13. PMID 10899003
    4. The diversity of O-linked glycans expressed during Drosophila melanogaster development reflects stage- and tissue-specific requirements for cell signaling. Aoki K, et al. J Biol Chem, 2008 Oct 31. PMID 18725413, Free PMC Article
    5. mirror controls planar polarity and equator formation through repression of fringe expression and through control of cell affinities. Yang CH, et al. Development, 1999 Dec. PMID 10572059

    See all (312) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Glycosylation of Specific Notch EGF Repeats by O-Fut1 and Fringe Regulates Notch Signaling in Drosophila.
      Title: Glycosylation of Specific Notch EGF Repeats by O-Fut1 and Fringe Regulates Notch Signaling in Drosophila.
    2. Mapping Sites of O-Glycosylation and Fringe Elongation on Drosophila Notch.
      Title: Mapping Sites of O-Glycosylation and Fringe Elongation on Drosophila Notch.
    3. The function of Chi and dLMO on Notch signaling is dependent on the regulation of fng transcription.
      Title: Chi and dLMO function antagonistically on Notch signaling through directly regulation of fng transcription.
    4. Fringe modulated Notch-ligand cis interactions during Drosophila development.
      Title: Fringe proteins modulate Notch-ligand cis and trans interactions to specify signaling states.
    5. FOXO-mediated regulation of fringe links the insulin and Notch signaling pathways in the germline stem cell niche.
      Title: FOXO/Fringe is necessary for maintenance of the germline stem cell niche in response to insulin insufficiency.
    6. Eaat1 expression is promoted by Fringe-mediated neuron-glial communication during development and suggest that Eaat1 plays an essential role in regulating central nervous system neural circuits that control locomotion in Drosophila
      Title: Drosophila glial glutamate transporter Eaat1 is regulated by fringe-mediated notch signaling and is essential for larval locomotion.
    7. the addition of N-acetylglucosamine is the basis for the effects of Fringe on Drosophila Notch-ligand binding
      Title: In vitro reconstitution of the modulation of Drosophila Notch-ligand binding by Fringe.
    8. suppresses effects of OFUT1 on Notch binding; decreases Serrate-Notch binding but increases Delta-Notch binding.
      Title: Modulation of notch-ligand binding by protein O-fucosyltransferase 1 and fringe.
    9. analysis of Drosophila Notch regions that contribute to ligand binding and the modulatory influence of Fringe
      Title: Regions of Drosophila Notch that contribute to ligand binding and the modulatory influence of Fringe.
    10. molecular genetic analysis
      Title: Molecular genetic analysis of the glycosyltransferase Fringe in Drosophila.
    Submit: New GeneRIF Correction See all GeneRIFs (13)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in compound eye development IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in compound eye morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cuticle pattern formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in dorsal/ventral pattern formation, imaginal disc IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in female germ-line stem cell population maintenance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in follicle cell of egg chamber development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in germarium-derived egg chamber formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in imaginal disc-derived leg morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in imaginal disc-derived leg segmentation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in imaginal disc-derived wing margin morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in imaginal disc-derived wing morphogenesis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in imaginal disc-derived wing morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of Notch signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of Notch signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in pattern specification process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of Notch signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of Notch signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein glycosylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein glycosylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of Notch signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in wing disc anterior/posterior pattern formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in wing disc dorsal/ventral pattern formation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in wing disc dorsal/ventral pattern formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Golgi medial cisterna IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi stack IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm HDA PubMed 
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    fringe
    Names
    CG10580-PA
    beta3-N-acetylglucosaminyltransferase
    fng-PA
    NP_524191.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      20925891..20949512 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079467.3 → NP_524191.1  fringe [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524191.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q24342, Q9VP97
      Related
      FBpp0077925
      Conserved Domains (1) summary
      pfam02434
      Location:145 → 394
      Fringe; Fringe-like
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q24342.1 Q24342

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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