snf-12 Sodium-dependent transporter snf-12 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: snf-12
Official Full Name: Sodium-dependent transporter snf-12
Primary source: WormBase:WBGene00004911
Locus tag: CELE_T25B6.7
See related: AllianceGenome:WB:WBGene00004911
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables STAT family protein binding activity. Involved in positive regulation of antifungal peptide production. Located in apical part of cell and endocytic vesicle. Is expressed in excretory cell; hypodermis; socket cell; and vulva. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See snf-12 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 12

Sequence:: Chromosome: X; NC_003284.9 (9029470..9033955)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The authors identify the STAT transcription factor-like protein STA-2 as a direct physical interactor of SNF-12 and show that the two proteins function together to regulate antimicrobial peptide gene expression in the epidermis.
Title: Unusual regulation of a STAT protein by an SLC6 family transporter in C. elegans epidermal innate immunity.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

T25B6.7 (e-PCR)
- UniSTS:312460

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables L-amino acid transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables STAT family protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables amino acid:sodium symporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables symporter activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in glycine import across plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of antifungal peptide production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sodium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in apical part of cell	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in endocytic vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in vesicle	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Sodium-dependent transporter snf-12

NP_509527.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

9029470..9033955

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_077126.4 → NP_509527.1 Sodium-dependent transporter snf-12 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_509527.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O45813

Conserved Domains (1) summary

cd10324
Location:158 → 660

SLC6sbd; Solute carrier 6 family, neurotransmitter transporters; solute-binding domain