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    ncx-5 Sodium/calcium exchanger membrane region domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 191715, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ncx-5
    Official Full Name
    Sodium/calcium exchanger membrane region domain-containing protein
    Primary source
    WormBase:WBGene00003570
    Locus tag
    CELE_Y32F6B.2
    See related
    AllianceGenome:WB:WBGene00003570
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable calcium channel activity and calcium, potassium:sodium antiporter activity. Predicted to be involved in calcium ion transmembrane transport and intracellular calcium ion homeostasis. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in oxygen sensory neurons. Human ortholog(s) of this gene implicated in congenital stationary night blindness 1D. Orthologous to human SLC24A1 (solute carrier family 24 member 1) and SLC24A2 (solute carrier family 24 member 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ncx-5 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    10
    Sequence:
    Chromosome: V; NC_003283.11 (10486361..10490098, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Cdc-42 Related Protein Neighboring gene ncRNA Neighboring gene Solute carrier organic anion transporter family member Neighboring gene ncRNA Neighboring gene AQuaPorin or aquaglyceroporin related

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Pan-phylum genome-wide identification of sodium calcium exchangers reveal heterogeneous expansions and possible roles in nematode parasitism. Bode K, et al. Gene, 2022 Feb 5. PMID 34756961
    2. High neural activity accelerates the decline of cognitive plasticity with age in Caenorhabditis elegans. Li Q, et al. Elife, 2020 Nov 24. PMID 33228848, Free PMC Article
    3. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    4. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables antiporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium, potassium:sodium antiporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in calcium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in calcium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular calcium ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in potassium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sodium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Sodium/calcium exchanger membrane region domain-containing protein
    NP_505690.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      10486361..10490098 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_073289.4 → NP_505690.2  Sodium/calcium exchanger membrane region domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_505690.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EC02
      Conserved Domains (1) summary
      pfam01699
      Location:486 → 642
      Na_Ca_ex; Sodium/calcium exchanger protein
    Nucleotide Protein
    Heading Accession and Version

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