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    tdc-1 Tyrosine decarboxylase [ Caenorhabditis elegans ]

    Gene ID: 174327, updated on 9-Dec-2024

    Summary

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    Official Symbol
    tdc-1
    Official Full Name
    Tyrosine decarboxylase
    Primary source
    WormBase:WBGene00006562
    Locus tag
    CELE_K01C8.3
    See related
    AllianceGenome:WB:WBGene00006562
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables tyrosine decarboxylase activity. Involved in octopamine biosynthetic process. Located in axon and neuronal cell body. Is expressed in hermaphrodite gonad and neurons. Human ortholog(s) of this gene implicated in Parkinson's disease; aromatic L-amino acid decarboxylase deficiency; bipolar disorder; inherited metabolic disorder; and nicotine dependence. Orthologous to human DDC (dopa decarboxylase). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See tdc-1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    10
    Sequence:
    Chromosome: II; NC_003280.10 (8270597..8273615)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene L-serine deaminase Neighboring gene CC domain-containing protein Neighboring gene ncRNA Neighboring gene GEX Interacting protein Neighboring gene Mitochondrial folate transporter/carrier Neighboring gene Large ribosomal subunit protein uL10m Neighboring gene C-type lectin domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Validation of onchocerciasis biomarker N-acetyltyramine-O-glucuronide (NATOG). Globisch D, et al. Bioorg Med Chem Lett, 2017 Aug 1. PMID 28600214, Free PMC Article
    2. A Change in the Ion Selectivity of Ligand-Gated Ion Channels Provides a Mechanism to Switch Behavior. Pirri JK, et al. PLoS Biol, 2015. PMID 26348462, Free PMC Article
    3. Nested Neuronal Dynamics Orchestrate a Behavioral Hierarchy across Timescales. Kaplan HS, et al. Neuron, 2020 Feb 5. PMID 31786012, Free PMC Article
    4. Memory in Caenorhabditis elegans is mediated by NMDA-type ionotropic glutamate receptors. Kano T, et al. Curr Biol, 2008 Jul 8. PMID 18583134, Free PMC Article
    5. A tyramine-gated chloride channel coordinates distinct motor programs of a Caenorhabditis elegans escape response. Pirri JK, et al. Neuron, 2009 May 28. PMID 19477154, Free PMC Article

    See all (45) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables carbon-carbon lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables carboxy-lyase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables carboxy-lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pyridoxal phosphate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tyrosine decarboxylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tyrosine decarboxylase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in amino acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in carboxylic acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in octopamine biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in axon IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in axon IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in perikaryon IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Tyrosine decarboxylase
    NP_495743.1
    • Confirmed by transcript evidence
    NP_495744.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      8270597..8273615
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_063343.4 → NP_495744.1  Tyrosine decarboxylase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_495744.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q95ZS2
      Conserved Domains (1) summary
      pfam00282
      Location:111 → 489
      Pyridoxal_deC; Pyridoxal-dependent decarboxylase conserved domain

    2. NM_063342.6 → NP_495743.1  Tyrosine decarboxylase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_495743.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q21087, Q95ZS2
      Conserved Domains (1) summary
      pfam00282
      Location:111 → 489
      Pyridoxal_deC; Pyridoxal-dependent decarboxylase conserved domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q95ZS2.1

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